Osteopontin, a bridge links osteoarthritis and osteoporosis

RJ Bai, YS Li, FJ Zhang - Frontiers in Endocrinology, 2022 - frontiersin.org
Osteoarthritis (OA) is the most prevalent joint disease characterized by degradation of
articular cartilage, inflammation, and changes in periarticular and subchondral bone of …

Nanomaterial-based reactive oxygen species scavengers for osteoarthritis therapy

S Zhang, L Wang, Y Kang, J Wu, Z Zhang - Acta Biomaterialia, 2023 - Elsevier
Reactive oxygen species (ROS) play distinct but important roles in physiological and
pathophysiological processes. Recent studies on osteoarthritis (OA) have suggested that …

Type H vessels—a bridge connecting subchondral bone remodelling and articular cartilage degeneration in osteoarthritis development

Y Liu, HQ Xie, B Shen - Rheumatology, 2023 - academic.oup.com
Recent studies have shed light on the cellular and molecular mechanisms that link
subchondral bone remodelling and angiogenesis in knee osteoarthritis (OA). Type H …

Single-cell RNA sequencing analysis of human chondrocytes reveals cell–cell communication alterations mediated by interactive signaling pathways in osteoarthritis

X Kang, K Zhang, Y Wang, Y Zhao, Y Lu - Frontiers in cell and …, 2023 - frontiersin.org
Objective: Osteoarthritis (OA) is a common joint disorder characterized by degenerative
articular cartilage, subchondral bone remodeling, and inflammation. Increasing evidence …

Osteopontin: a bone-derived protein involved in rheumatoid arthritis and osteoarthritis immunopathology

BT Martín-Márquez, F Sandoval-García… - Biomolecules, 2023 - mdpi.com
Osteopontin (OPN) is a bone-derived phosphoglycoprotein related to physiological and
pathological mechanisms that nowadays has gained relevance due to its role in the immune …

Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 …

Y Wang, W Zhang, Y Yang, J Qin, R Wang, S Wang… - Bone Research, 2024 - nature.com
Intervertebral disc degeneration (IDD) is a major cause of discogenic pain, and is attributed
to the dysfunction of nucleus pulposus, annulus fibrosus, and cartilaginous endplate (CEP) …

Signalling interaction between β‐catenin and other signalling molecules during osteoarthritis development

J Feng, Q Zhang, F Pu, Z Zhu, K Lu, WW Lu… - Cell …, 2024 - Wiley Online Library
Osteoarthritis (OA) is the most prevalent disorder of synovial joint affecting multiple joints. In
the past decade, we have witnessed conceptual switch of OA pathogenesis from a 'wear and …

Pathological progression of osteoarthritis: a perspective on subchondral bone

X Li, W Chen, D Liu, P Chen, S Wang, F Li, Q Chen… - Frontiers of …, 2024 - Springer
Osteoarthritis (OA) is a degenerative bone disease associated with aging. The rising global
aging population has led to a surge in OA cases, thereby imposing a significant …

Roles of circular RNAs in osteogenic differentiation of bone marrow mesenchymal stem cells

J Wang, T Wang, F Zhang, Y Zhang… - Molecular …, 2022 - spandidos-publications.com
Bone marrow mesenchymal stem cells (BMSCs) can differentiate into osteoblasts,
chondrocytes, adipocytes and even myoblasts, and are therefore defined as pluripotent …

Association between the prevalence of pulp stones and calcified atherosclerotic plaques: a systematic review and meta-analysis

WA Vieira, LR Paranhos… - Dentomaxillofacial …, 2023 - academic.oup.com
Objective: To evaluate the association between the prevalence of pulp stones (PS) in
permanent teeth and calcified atherosclerotic plaques (CAP). Methods: An electronic search …