Crosspresentation is a specialized function of myeloid dendritic cells (mDCs), allowing them
to induce CD8+ T cell responses against exogenous antigens that are not directly produced …

Bronchial asthma is a chronic disorder characterized by airway inflammation, reversible
airway obstruction, and airway hyperresponsiveness. Eosinophils are believed to play …

The molecular mechanisms that drive mucosal T helper type 2 (TH2) responses against
parasitic helminths and allergens remain unclear. In this study, we demonstrate in mice that …

Fibrosis and structural remodeling of the lung tissue can significantly impair lung function,
often with fatal consequences. The etiology of pulmonary fibrosis (PF) is diverse and …

Airway DCs play a crucial role in the pathogenesis of allergic asthma, and interfering with
their function could constitute a novel form of therapy. The sphingosine 1–phosphate …

Allergic asthma is a chronic airway inflammatory disease in which exposure to allergens
causes intermittent attacks of breathlessness, airway hyper-reactivity, wheezing, and …

Respiratory syncytial virus (RSV) infection is widely spread and is a major cause of
bronchiolitis in infants and high-risk adults, often leading to hospitalization. RSV infection …

The roles of macrophages in type 2-driven inflammation and fibrosis remain unclear. Here,
using CD11b-diphtheria toxin receptor (DTR) transgenic mice and three models of …

Cells of the mononuclear phagocyte system (MPS) are found in large numbers in every
organ of the body, where they contribute to innate and acquired immunity and homeostasis …

At present, therapeutic interventions to treat acute lung injury (ALI) or acute respiratory
distress syndrome (ARDS) remain largely limited to lung-protective strategies, as no real …