Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …

Pancreatic ductal adenocarcinoma is prone to distant metastasis and is expected to become
the second leading cause of cancer-related death. In an extremely nutrient-deficient and …

Pancreatic cystic lesions (PCLs) are well-known precursors of pancreatic cancer. Their
diagnosis can be challenging as their behavior varies from benign to malignant disease …

Pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC), presents a
challenging landscape due to its complex nature and the highly immunosuppressive tumor …

Cancer is a systemic disease that involves malignant cell-intrinsic and-extrinsic metabolic
adaptations. Most studies have tended to focus on elucidating the metabolic vulnerabilities …

Simple Summary Tumor recurrence still represents a major clinical challenge for cancer
patients. Cancer cells may undergo a dormant state for long times before re-emerging. Both …

Despite significant improvements in clinical management, pancreatic cancer (PC) remains
one of the deadliest cancer types, as it is prone to late detection with extreme metastatic …

Background and aims The crosstalk between cancer stem cells (CSCs) and their niche is
required for the maintenance of stem cell-like phenotypes of CSCs. Here, we identified E26 …

Despite gains in knowledge of the intrinsic signals governing cancer progression, effective
clinical management of cancer remains a challenge. Drug resistance and relapse, pose the …

Understanding the governing principles behind organisms' metabolism and growth
underpins their effective deployment as bioproduction chassis. A central objective of …