Compelling evidence for the inherited nature of essential hypertension has led to extensive
research in rats and humans. Rats have served as the primary model for research on the …

Essential hypertension (EH) is a complex, polygenic condition with no single causative
agent. Despite advances in our understanding of the pathophysiology of EH, hypertension …

Hypertension is defined as a persistently elevated blood pressure≥ 140/90 mm Hg. It is an
important treatable risk factor for cardiovascular disease, with a high prevalence in the …

Genetic variants play an important role in conferring risk for cardiovascular diseases (CVDs).
With the rapid development of next-generation sequencing (NGS), thousands of genetic …

The clinical value of the polygenetic component of blood pressure (BP) is commonly
questioned. We evaluated a genetic risk score for BP (BP-GRS858), based on the most …

Blood pressure has a significant genetic component, but less than 3% of the observed
variance has been attributed to genetic variants identified to date. Candidate gene studies of …

La regulación de la presión arterial (PA) es un proceso complejo, con intervención de
múltiples variantes genéticas y epigenéticas que son objeto de la presente revisión. La …

Essential hypertension is characterized by chronic elevation of blood pressure (BP) due to
an unknown cause. It affects nearly 95% of hypertensive patients [1]. Genetic causes …

The incidence of hypertension, the major modifiable risk factor for cardiovascular disease, is
increasing. Thus, there is a pressing need for the development of new and more effective …

Background Several attempts to decipher the genetics of hypertension of unknown causes
have been made including large-scale genome-wide association analysis (GWA), but only a …