[HTML][HTML] Toward computational neuroconstructivism: a framework for developmental systems neuroscience

DE Astle, MH Johnson, D Akarca - Trends in Cognitive Sciences, 2023 - cell.com
Brain development is underpinned by complex interactions between neural assemblies,
driving structural and functional change. This neuroconstructivism (the notion that neural …

[HTML][HTML] Spatially embedded recurrent neural networks reveal widespread links between structural and functional neuroscience findings

J Achterberg, D Akarca, DJ Strouse, J Duncan… - Nature Machine …, 2023 - nature.com
Brain networks exist within the confines of resource limitations. As a result, a brain network
must overcome the metabolic costs of growing and sustaining the network within its physical …

[HTML][HTML] Computational models of typical and atypical brain network development

PE Vértes - Biological Psychiatry, 2023 - Elsevier
Over the last decade, the organization of brain networks at both micro-and macroscales has
become a key focus of neuroscientific inquiry. This has revealed fundamental features of …

The adaptive stochasticity hypothesis: Modeling equifinality, multifinality, and adaptation to adversity

S Carozza, D Akarca, D Astle - Proceedings of the National …, 2023 - National Acad Sciences
Neural phenotypes are the result of probabilistic developmental processes. This means that
stochasticity is an intrinsic aspect of the brain as it self-organizes over a protracted period. In …

[HTML][HTML] Parameter estimation for connectome generative models: Accuracy, reliability, and a fast parameter fitting method

Y Liu, C Seguin, S Mansour, S Oldham, R Betzel… - Neuroimage, 2023 - Elsevier
Generative models of the human connectome enable in silico generation of brain networks
based on probabilistic wiring rules. These wiring rules are governed by a small number of …

[HTML][HTML] Long-term morphological and functional dynamics of human stem cell-derived neuronal networks on high-density micro-electrode arrays

R Habibey, J Striebel, F Schmieder, J Czarske… - Frontiers in …, 2022 - frontiersin.org
Comprehensive electrophysiological characterizations of human induced pluripotent stem
cell (hiPSC)-derived neuronal networks are essential to determine to what extent these in …

A weighted generative model of the human connectome

D Akarca, S Schiavi, J Achterberg, S Genc, DK Jones… - bioRxiv, 2023 - biorxiv.org
Probabilistic generative network models have offered an exciting window into the constraints
governing the human connectome's organization. In particular, they have highlighted the …

Early adversity changes the economic conditions of mouse structural brain network organization

S Carozza, J Holmes, PE Vértes… - Developmental …, 2023 - Wiley Online Library
Early adversity can change educational, cognitive, and mental health outcomes. However,
the neural processes through which early adversity exerts these effects remain largely …

Early adversity changes the economic conditions of structural brain network organisation

S Carozza, J Holmes, PE Vértes, E Bullmore, TM Arefin… - BioRxiv, 2022 - biorxiv.org
Early adversity can change educational, cognitive, and mental health outcomes. However,
the neural processes through which early adversity exerts these effects remain largely …

[HTML][HTML] Preconfigured architecture of the developing mouse brain

M Chini, M Hnida, JK Kostka, YN Chen… - Cell Reports, 2024 - cell.com
In the adult brain, structural and functional parameters, such as synaptic sizes and neuronal
firing rates, follow right-skewed and heavy-tailed distributions. While this organization is …