The alternative matrisome: alternative splicing of ECM proteins in development, homeostasis and tumor progression

Z Rekad, V Izzi, R Lamba, D Ciais… - Matrix Biology, 2022 - Elsevier
The extracellular matrix (ECM) is a fundamental component of the tissue of multicellular
organisms that is comprised of an intricate network of multidomain proteins and associated …

[HTML][HTML] Alternative pre-mRNA splicing as a mechanism for terminating Toll-like Receptor signaling

FFY Lee, S Alper - Frontiers in Immunology, 2022 - frontiersin.org
While inflammation induced by Toll-like receptor (TLR) signaling is required to combat
infection, persistent inflammation can damage host tissues and contribute to a myriad of …

Mapping the splicing landscape of the human immune system

H Ner-Gaon, R Peleg, R Gazit… - Frontiers in …, 2023 - frontiersin.org
Most human genes code for more than one transcript. Different ratios of transcripts of the
same gene can be found in different cell types or states, indicating differential use of …

Immunomodulatory gene-splicing dysregulation in tumorigenesis: unmasking the complexity

LT Maebele, TV Mulaudzi, M Yasasve, Z Dlamini… - Molecules, 2023 - mdpi.com
Cancer is a global health concern with rising incidence, morbidity, and mortality. The
interaction between the tumor and immune cells within the tumor microenvironment is …

Talaromyces marneffei suppresses macrophage inflammation by regulating host alternative splicing

W Wei, G Wang, H Zhang, X Bao, S An, Q Luo… - Communications …, 2023 - nature.com
Talaromyces marneffei (T. marneffei) immune escape is essential in the pathogenesis of
talaromycosis. It is currently known that T. marneffei achieves immune escape through …

RNA‐Binding Proteins and Alternative Splicing Genes Are Coregulated in Human Retinal Endothelial Cells Treated with High Glucose

H Zhao, H Kong, B Wang, S Wu… - Journal of Diabetes …, 2022 - Wiley Online Library
To explore the relevant RNA‐binding proteins (RBPs) and alternative splicing events (ASEs)
in diabetic retinopathy (DR). We devised a comprehensive work to integrate analyses of the …

[HTML][HTML] Brucella abortus triggers the differential expression of immunomodulatory lncRNAs in infected murine macrophages

M Flores-Concha, LA Gómez, R Soto-Shara… - Frontiers in …, 2024 - frontiersin.org
Introduction The lncRNAs (long non-coding RNAs) are the most diverse group of non-coding
RNAs and are involved in most biological processes including the immune response. While …

A novel 16-gene alternative mRNA splicing signature predicts tumor relapse and indicates immune activity in stage I–III hepatocellular carcinoma

XX Chen, BH Zhang, YC Lu, ZQ Li, CY Chen… - Frontiers in …, 2022 - frontiersin.org
Background: Hepatocellular carcinoma (HCC) is a lethal disease with high relapse and
dismal survival rates. Alternative splicing (AS) plays a crucial role in tumor progression …

Molecular mechanism of lncRNAs in pathogenesis and diagnosis of auto-immune diseases, with a special focus on lncRNA-based therapeutic approaches

A Mehmandar-Oskuie, K Jahankhani, A Rostamlou… - Life Sciences, 2023 - Elsevier
Autoimmune diseases are a diverse set of conditions defined by organ damage due to
abnormal innate and acquired immune system responses. The pathophysiology of …

Unveiling the Role of Dynamic Alternative Splicing Modulation After Infestation with Sea Lice (Caligus rogercresseyi) in Atlantic Salmon

S Bravo, F Leiva, J Moya, O Guzman, R Vidal - Marine Biotechnology, 2023 - Springer
Sea lice are pathogenic marine ectoparasite copepods that represent a severe risk to the
worldwide salmon industry. Several transcriptomic investigations have characterized the …