RNA-mediated epigenetic regulation in exercised heart: Mechanisms and opportunities for intervention

L Wang, W Wan, S Zhang, T Keswani, G Li… - Molecular Aspects of …, 2024 - Elsevier
Physical exercise has been widely acknowledged as a beneficial lifestyle alteration and a
potent non-pharmacological treatment for heart disease. Extensive investigations have …

Exercise training decreases lactylation and prevents myocardial ischemia–reperfusion injury by inhibiting YTHDF2

G Xu, P Yu, Y Hu, W Wan, K Shen, X Cui… - Basic Research in …, 2024 - Springer
Exercise improves cardiac function and metabolism. Although long-term exercise leads to
circulating and micro-environmental metabolic changes, the effect of exercise on protein …

RNA modifications in physiology and pathology: Progressing towards application in clinical settings

X Jiang, L Zhan, X Tang - Cellular Signalling, 2024 - Elsevier
The potential to modify individual nucleotides through chemical means in order to impact the
electrostatic charge, hydrophobic properties, and base pairing of RNA molecules is …

TransAC4C—a novel interpretable architecture for multi-species identification of N4-acetylcytidine sites in RNA with single-base resolution

R Liu, Y Zhang, Q Wang, X Zhang - Briefings in Bioinformatics, 2024 - academic.oup.com
Abstract N4-acetylcytidine (ac4C) is a modification found in ribonucleic acid (RNA) related to
diseases. Expensive and labor-intensive methods hindered the exploration of ac4C …

Pseudouridine in RNA: Enzymatic Synthesis Mechanisms and Functional Roles in Molecular Biology

A Khan, YD Hu, S Khan, SM Aqeel… - International …, 2023 - i.agriculturejournals.org
Pseudouridine, a common modified nucleotide, is prevalent in bacterial tRNA, rRNA, and
snRNA. Initially identified in rRNA and tRNA, its presence extends to snRNA. Despite being …