Discovery of novel anti-angiogenesis agents. Part 7: Multitarget inhibitors of VEGFR-2, TIE-2 and EphB4
C Li, Y Shan, Y Sun, R Si, L Liang, X Pan… - European Journal of …, 2017 - Elsevier
Herein, we embarked on a structural optimization campaign aiming at the discovery of
second generation anti-angiogenesis agents with our previously reported BPS-7 as lead …
second generation anti-angiogenesis agents with our previously reported BPS-7 as lead …
Medicinal attributes of thienopyrimidine scaffolds incorporating the aryl urea motif as potential anticancer candidates via VEGFR inhibition
MA Farag, MM Kandeel, AE Kassab… - Archiv der …, 2024 - Wiley Online Library
Worldwide, cancer is a major public health concern. It is a well‐acknowledged life‐
threatening disease. Despite numerous advances in the understanding of the genetic basis …
threatening disease. Despite numerous advances in the understanding of the genetic basis …
New 6-nitro-4-substituted quinazoline derivatives targeting epidermal growth factor receptor: design, synthesis and in vitro anticancer studies
AB Farag, AH Othman, MK El-Ashrey… - Future Medicinal …, 2024 - Taylor & Francis
Aim: Twenty compounds of 6-nitro-4-substituted quinazolines were synthesized. Materials &
methods: The new derivatives were evaluated for their epidermal growth factor receptor …
methods: The new derivatives were evaluated for their epidermal growth factor receptor …
Discovery of novel VEGFR-2 inhibitors. Part 5: Exploration of diverse hinge-binding fragments via core-refining approach
Y Shan, H Gao, X Shao, J Wang, X Pan… - European Journal of …, 2015 - Elsevier
Pathological angiogenesis plays a critical role in numerous diseases including malignancy.
VEGFR-2 is the central regulators in angiogenesis and has become a promising target for …
VEGFR-2 is the central regulators in angiogenesis and has become a promising target for …
Facile one-pot sequential synthesis of novel diaryl urea derivatives and evaluation of their in vitro cytotoxicity on adenocarcinoma cells
F Azimian, M Hamzeh-Mivehroud… - Medicinal Chemistry …, 2021 - Springer
Recently, the diarylurea scaffold has been used widely to design potential anticancer
agents. Pursuing our design strategy based on the modification of sorafenib as the lead …
agents. Pursuing our design strategy based on the modification of sorafenib as the lead …
Expanding the structural diversity of diarylureas as multi-target tyrosine kinase inhibitors
Y Shan, C Wang, L Zhang, J Wang, M Wang… - Bioorganic & Medicinal …, 2016 - Elsevier
Recently approved multi-target inhibitors of receptor tyrosine kinases (RTKs) have
significantly improved the clinical treatment of cancers. A series of N, N′-diarylureas …
significantly improved the clinical treatment of cancers. A series of N, N′-diarylureas …
New strategies in achieving antiangiogenic effect: Multiplex inhibitors suppressing compensatory activations of RTKs
Y Shan, B Wang, J Zhang - Medicinal Research Reviews, 2018 - Wiley Online Library
Pathological angiogenesis plays a crucial role in malignant neoplasia. Vascular
normalization has been confirmed as a promising strategy to promote chemotherapy …
normalization has been confirmed as a promising strategy to promote chemotherapy …
Discovery of biphenyl-based VEGFR-2 inhibitors. Part 3: design, synthesis and 3D-QSAR studies
W Lu, P Li, Y Shan, P Su, J Wang, Y Shi… - Bioorganic & Medicinal …, 2015 - Elsevier
VEGFR-2 plays an essential role in angiogenesis and is a central target for anticancer drug
discovery. In order to develop novel VEGFR-2 inhibitors, we designed and synthesized 33 …
discovery. In order to develop novel VEGFR-2 inhibitors, we designed and synthesized 33 …
Novel multi-target angiogenesis inhibitors as potential anticancer agents: Design, synthesis and preliminary activity evaluation
Q Zhang, Z Li, J Zhang, Y Li, X Pan, J Qu, J Zhang - Bioorganic Chemistry, 2024 - Elsevier
Based on the crucial role of histone deacetylase (HDAC) and receptor tyrosine kinase in
angiogenesis, in situ assembly, skeletal transition, molecular hybridization, and …
angiogenesis, in situ assembly, skeletal transition, molecular hybridization, and …
Design, synthesis and biological evaluation of thiourea and nicotinamide-containing sorafenib analogs as antitumor agents
X Kong, Z Yao, Z He, W Xu, J Yao - MedChemComm, 2015 - pubs.rsc.org
A series of thiourea and nicotinamide-containing sorafenib analogs (7a–n) were designed
and synthesized and their antiproliferative activities were tested against HCT116, MDA-MB …
and synthesized and their antiproliferative activities were tested against HCT116, MDA-MB …