Tumor neovascularization provides abundant nutrients for the occurrence and development
of tumors, and is also an important factor in tumor invasion and metastasis, which has …

Based on the crucial role of histone deacetylase (HDAC) and receptor tyrosine kinase in
angiogenesis, in situ assembly, skeletal transition, molecular hybridization, and …

The quest for novel, physiologically active imidazoles remains an exciting topic of research
among medicinal chemists. The imidazole ring is a five-membered aromatic heterocycle that …

In this study, 36 crystal structures available with type IV inhibitors of VEGFR-2 kinase in the
RCSB PDB were classified into DFG-in/-out conformation using visual analysis and KLIFS …

A series of novel biaryl ureas containing different structural patterns have been prepared in
good yields in the presence of palladium nanoparticles (PdNPs) with narrow particle size …

A novel series of 5-bromo-pyrimidine derivatives (5a-l, 6a-h, 9a-m and 10a-d) were
synthesized through multi step reactions starting from 5-bromo-2, 4-dichloro pyrimidine. The …

Previously, we described the discovery of potent ferulic acid-based histone deacetylase
inhibitors (HDACIs) with halogeno-acetanilide as novel surface recognition moiety (SRM). In …

Chronic hypertension induces vascular remodeling. The most important factor for
hypertension treatment is reducing the risk of cardiovascular disease. OW1 is a novel …

Angiogenesis is the process of formation of new capillaries from preexisting blood vessels.
Angiogenesis is involved in normal physiological processes, and plays an important role in …

Amino‐5‐(thiazol‐2‐yl)‐[1, 1′‐biaryl]‐2, 4‐dicarbonitriles have been synthesized
employing a facile one‐pot pseudo four‐component domino strategy. All these thiazole …