Discovery of novel Bcr–Abl inhibitors targeting myristoyl pocket and ATP site
Bcr–Abl plays an essential role in the pathogenesis and development of chronic myeloid
leukaemia (CML). Inhibition of Bcr–Abl has great potential for therapeutic intervention in …
leukaemia (CML). Inhibition of Bcr–Abl has great potential for therapeutic intervention in …
[PDF][PDF] A theoretical analysis of the inhibition of the VEGFR-2 vascular endothelial growth factor and the anti-proliferative activity against the HepG2 hepatocellular …
JS Gómez-Jeria, Í Orellana - Der Pharma Chem, 2016 - researchgate.net
An analysis of the relationships between electronic structure and the inhibition of the kinase
activity of VEGFR-2 was carried out for a series of 1-(4-((2-oxoindolin-3-ylidene) amino) …
activity of VEGFR-2 was carried out for a series of 1-(4-((2-oxoindolin-3-ylidene) amino) …
Arylurea Derivatives: A Class of Potential Cancer Targeting Agents
JN Chen, DW Wu, T Li, KJ Yang… - Current topics in …, 2017 - ingentaconnect.com
Arylurea derivatives, an important class of small molecules, have received considerable
attention in recent years due to their wide range of biological applications. Various …
attention in recent years due to their wide range of biological applications. Various …
TPD7 inhibits the growth of cutaneous T cell lymphoma H9 cell through regulating IL‐2R signalling pathway
M Zhu, L Yang, X Shi, Z Gong, R Yu… - Journal of Cellular …, 2020 - Wiley Online Library
IL‐2R pathway is a key regulator in the development of immune cells and has emerged as a
promising drug target in cancer treatment, but there is a scarcity of related inhibitors. TPD7 is …
promising drug target in cancer treatment, but there is a scarcity of related inhibitors. TPD7 is …
Design, synthesis and broad-spectrum Bcr-Abl inhibitory activity of novel thiazolamide–benzamide derivatives
J Liu, H Huang, X Deng, R Xiong, X Cao, G Tang… - RSC …, 2019 - pubs.rsc.org
Bcr-Abl plays an important role in the pathogenesis and development of chronic myeloid
leukemia (CML). But Bcr-Abl is prone to mutation, so it increases the difficulty of clinical …
leukemia (CML). But Bcr-Abl is prone to mutation, so it increases the difficulty of clinical …
Pharmacophore and docking guided virtual screening study for discovery of type I inhibitors of VEGFR-2 kinase
HR Bhojwani, UJ Joshi - Current Computer-Aided Drug …, 2017 - ingentaconnect.com
Background: Kinase domain of VEGFR-2 displays conformational flexibility which leads to
existence of two kinds of inhibitors viz. type I and type II inhibitors. They exhibit different …
existence of two kinds of inhibitors viz. type I and type II inhibitors. They exhibit different …
[HTML][HTML] Design, synthesis and biological evaluation of phenylpicolinamide sorafenib derivatives as antitumor agents
C Wu, S Xu, Y Guo, J Wu, R Luo, W Wang, Y Tu… - Medicinal Chemistry …, 2018 - Springer
Two series of phenylpicolinamide sorafenib derivatives (14a–k, 15a–k) were designed and
synthesized. They were evaluated for IC 50 values against three cancer cell lines (A549 …
synthesized. They were evaluated for IC 50 values against three cancer cell lines (A549 …
Spontaneous and Direct Transformation of N, O-Diaryl Carbamates into N, N′-Diarylureas
R Yamasaki, Y Honjo, A Ito, K Fukuda… - Chemical and …, 2018 - jstage.jst.go.jp
We have discovered a spontaneous reaction of N, O-diaryl carbamates to afford symmetrical
N, N′-diarylureas. Optimization of the conditions indicated that N, N-dimethylformamide …
N, N′-diarylureas. Optimization of the conditions indicated that N, N-dimethylformamide …
Synthesis, docking and biological evaluation of 2, 4-disubstituted quinazolines with multi-target activities as anti-cancer and antimicrobial agents
MT El-Saadi, NH Amin - Egyptian Journal of Chemistry, 2020 - journals.ekb.eg
A series of 2, 4-disubstituted quinazoline derivatives was designed and synthesized as multi-
target therapeutic agents that may act as anti-cancer and antimicrobial agents. The target …
target therapeutic agents that may act as anti-cancer and antimicrobial agents. The target …
Design, Synthesis and Biological Evaluation of 2-Phenoxy-N-Phenylacetamides as Novel Anticancer Agents
Y Shan, F Liu, Y Ma, T Fan, M Wang, Y Dong - Pharmaceutical Chemistry …, 2016 - Springer
A series of 2-phenoxy-N-phenylacetamides were designed and synthesized with a view to
develop novel anticancer agents. All compounds were prepared with varied substitutions in …
develop novel anticancer agents. All compounds were prepared with varied substitutions in …