Bcr–Abl plays an essential role in the pathogenesis and development of chronic myeloid
leukaemia (CML). Inhibition of Bcr–Abl has great potential for therapeutic intervention in …

An analysis of the relationships between electronic structure and the inhibition of the kinase
activity of VEGFR-2 was carried out for a series of 1-(4-((2-oxoindolin-3-ylidene) amino) …

Arylurea derivatives, an important class of small molecules, have received considerable
attention in recent years due to their wide range of biological applications. Various …

IL‐2R pathway is a key regulator in the development of immune cells and has emerged as a
promising drug target in cancer treatment, but there is a scarcity of related inhibitors. TPD7 is …

Bcr-Abl plays an important role in the pathogenesis and development of chronic myeloid
leukemia (CML). But Bcr-Abl is prone to mutation, so it increases the difficulty of clinical …

Background: Kinase domain of VEGFR-2 displays conformational flexibility which leads to
existence of two kinds of inhibitors viz. type I and type II inhibitors. They exhibit different …

Two series of phenylpicolinamide sorafenib derivatives (14a–k, 15a–k) were designed and
synthesized. They were evaluated for IC 50 values against three cancer cell lines (A549 …

We have discovered a spontaneous reaction of N, O-diaryl carbamates to afford symmetrical
N, N′-diarylureas. Optimization of the conditions indicated that N, N-dimethylformamide …

A series of 2, 4-disubstituted quinazoline derivatives was designed and synthesized as multi-
target therapeutic agents that may act as anti-cancer and antimicrobial agents. The target …

A series of 2-phenoxy-N-phenylacetamides were designed and synthesized with a view to
develop novel anticancer agents. All compounds were prepared with varied substitutions in …