Design, synthesis, and biological evaluation of tetrahydroisoquinoline-based diaryl urea derivatives for suppressing VEGFR-2 signaling

Y Huang, Y Zhang, J Li, X Ma, M Hu, Y Yang… - Anti-Cancer …, 2019 - journals.lww.com
A novel structural series of tetrahydroisoquinoline-based compounds that incorporate the
diaryl urea moiety was designed, synthesized, and biologically evaluated as suppressors of …

Synthesis and Biological Evaluation of Pyrimidine Analogs

B Ballur, S Puranik - Journal of Current Pharma Research, 2023 - search.proquest.com
Their action sequences employed for synthesis of target2-(2-(5bromo-2-
morpholinopyrimidin-4-ylamino) thiazol-4yl) acetohydrazideand5-((2-(5-bromo-2 …

[PDF][PDF] CONCISE ARTICLE

H Dong, C Dong, W Xia, Y Li, T Ren - Citeseer
A novel prodrug of pegylated methotrexate conjugates (PMCs) with a high drug-carrying
capability and a redox sensitive drug release mechanism was reported for intracellular drug …

Synthesis, Biological Evaluation and Docking Studies of Sorafenib Derivatives N-(3-fluoro-4-(pyridin-4-yloxy) phenyl)-4 (5)-phenylpicolinamides

M Wang, C Wu, S Xu, Y Zhu, W Li, P Zheng… - Medicinal …, 2017 - ingentaconnect.com
Background: Sorafenib is an important VEGFR2/KDR inhibitor which is widely used for the
treatment of cancer. Objective: In this paper, two series of sorafenib analogues N-(3-fluoro-4 …

Receptor Tyrosine Kinase Inhibitory Activities and Molecular Docking Studies of Some Pyrrolo [2, 3-d] pyrimidine Derivatives

Z Kilic-Kurt, EE Kurt, F Bakar-Ates - Iranian Journal of …, 2019 - vclass.sbmu.ac.ir
In this study, we aimed to determine VEGFR-2, EGFR and PDGFR-β tyrosine kinase
inhibitory activities of some pyrrolo [2, 3-d] pyrimidine derivatives previously synthesized and …