The aetiology of systemic lupus erythematosus (SLE) is multifactorial, and includes
contributions from the environment, stochastic factors, and genetic susceptibility. Great gains …

Lupus is a chronic, autoimmune multisystem inflam-matory disease that is associated with
sizable morbidity and mortality. 1 When lupus commences in an individual less than 18 …

Objective Systemic lupus erythematosus (SLE) is a prototype autoimmune disease that is
assumed to occur via a complex interplay of environmental and genetic factors. Rare causes …

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disease with highest
prevalence among women of childbearing age. However, children younger than 16 years …

Autoimmune and immunodeficiency diseases are outcomes of a dysfunctional immune
system and represent 2 sides of the same coin. Multiple single-gene defects have been …

Paediatric-onset systemic lupus erythematosus (SLE) is usually more severe than its adult
counterpart. In particular, there is a higher incidence of renal and central nervous system …

About 20% of systemic lupus erythematosus (SLE) starts in childhood and children have
less gender bias in favor of females as compared to adults. Systemic manifestations …

In this study, we aimed to systematically review available literature on the efficacy of
eculizumab for the treatment of renal involvement in patients with systemic lupus …

Background Treatment of systemic lupus erythematosus (SLE) with severe diffuse
proliferative nephritis is often challenging, particularly in small children in whom a genetic …

Autoimmunity may be a manifestation of inborn errors of immunity, specifically as part of the
subgroup of primary immunodeficiency known as primary immune regulatory disorders …