Infantile spasms: outcome in clinical studies

R Riikonen - Pediatric neurology, 2020 - Elsevier
Children with infantile spasms are likely to have a poor outcome. Outcome measures for
infantile spasms include primary response to treatment, relapse of spasms, neurological …

Treatment of children with infantile spasms: A network meta‐analysis

P Jain, JK Sahu, PS Horn, V Chau, C Go… - … Medicine & Child …, 2022 - Wiley Online Library
Aim We performed a systematic review and network meta‐analysis (NMA) to obtain
comparative effectiveness estimates and rankings of non‐surgical interventions used to treat …

The severe epilepsy syndromes of infancy: a population‐based study

KB Howell, JL Freeman, MT Mackay, MC Fahey… - …, 2021 - Wiley Online Library
Objective To study the epilepsy syndromes among the severe epilepsies of infancy and
assess their incidence, etiologies, and outcomes. Methods A population‐based cohort study …

Scalp EEG interictal high frequency oscillations as an objective biomarker of infantile spasms

H Nariai, SA Hussain, D Bernardo, H Motoi… - Clinical …, 2020 - Elsevier
Objective To investigate the diagnostic utility of high frequency oscillations (HFOs) via scalp
electroencephalogram (EEG) in infantile spasms. Methods We retrospectively analyzed …

Tuber locations associated with infantile spasms map to a common brain network

AL Cohen, BPF Mulder, AK Prohl… - Annals of …, 2021 - Wiley Online Library
Objective Approximately 50% of patients with tuberous sclerosis complex develop infantile
spasms, a sudden onset epilepsy syndrome associated with poor neurological outcomes …

Safety and efficacy of melatonin supplementation as an add‐on treatment for infantile epileptic spasms syndrome: A randomized, placebo‐controlled, double‐blind …

Y Sun, J Chen, X Shi, Z Li, L Wan, H Yan… - Journal of pineal …, 2024 - Wiley Online Library
This was a prospective, randomized, double‐blind, single‐center placebo‐controlled trial to
assess the efficacy and safety of melatonin as an add‐on treatment for infantile epileptic …

Fulminant vigabatrin toxicity during combination therapy with adrenocorticotropic hormone for infantile spasms: Three cases and review of the literature

S Bhalla, K Skjei - Epilepsia, 2020 - Wiley Online Library
Abstract Vigabatrin (VGB), adrenocorticotropic hormone (ACTH), and prednisone are first‐
line treatments for infantile spasms (IS). A recent study reported benefits from the use of …

Infantile spasms: Assessing the diagnostic yield of an institutional guideline and the impact of etiology on long‐term treatment response

N Chourasia, CJ Yuskaitis, MH Libenson… - …, 2022 - Wiley Online Library
Objective Neuroimaging and genetic testing have been proposed for diagnostic evaluation
of infantile spasms (IS), establishing etiology in~ 60% of multicenter IS cohorts. A …

Three different scenarios for epileptic spasms

L Fusco, D Serino, ME Santarone - Epilepsy & Behavior, 2020 - Elsevier
Epileptic Spasms (ES) is a type of seizure usually occurring in the context of a severe
childhood epileptic syndrome associated to significant Electroencephalogram (EEG) …

Epilepsy syndromes in cerebral palsy: varied, evolving and mostly self-limited

MS Cooper, MT Mackay, C Dagia, MC Fahey… - Brain, 2023 - academic.oup.com
Seizures occur in approximately one-third of children with cerebral palsy. This study aimed
to determine epilepsy syndromes in children with seizures and cerebral palsy due to …