Genome‐wide association studies (GWAS) have identified numerous disease‐associated
variants; however, these variants have a minor effect on disease and explain only a small …

Advances in molecular biology have provided tools for studying the epigenetic factors that
modulate gene expression. DNA methylation is an epigenetic modification that can have …

Methotrexate (MTX) is a well-known antimetabolite that blocks the action of dihydrofolate
reductase, thereby inhibiting the metabolism of folic acid. It has been used widely since the …

DNA methylation is an epigenetic modification involved in organism development and
cellular differentiation. Identifying differential methylations can help to study genomic regions …

Lung cancer demonstrates the highest mortality in the UK. Previous studies have implicated
allelic loss at chromosome 17q in the development of non-small cell lung carcinoma …

DNA methylation is a key regulator of gene transcription. Alterations in DNA methylation
patterns are common in most cancers, occur early in carcinogenesis and can be detected in …

Aberrant methylation of promoter CpG islands is associated with transcriptional inactivation
of tumor-suppressor genes in cancer. TFPI2, a Kunitz-type serine proteinase inhibitor, has …

The oral cavity is the sixth most common anatomical localization of head and neck
carcinoma in men. Detection of oral carcinomas in the early asymptomatic stages improves …

Based on the methylation status of 5 single CpG sites, a novel epigenetic classification of
chronic lymphocytic leukemia (CLL) was recently proposed, classifying CLL patients into 3 …

OBJECTIVES: Urinary hypermethylation of BCL2, hTERT, and DAPK promoters has been
previously demonstrated as an accurate biomarker for the detection of urothelial carcinoma …