KIT (CD117): a review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation
M Miettinen, J Lasota - Applied immunohistochemistry & molecular …, 2005 - journals.lww.com
CD117 (KIT) is a type III receptor tyrosine kinase operating in cell signal transduction in
several cell types. Normally KIT is activated (phosphorylated) by binding of its ligand, the …
several cell types. Normally KIT is activated (phosphorylated) by binding of its ligand, the …
[HTML][HTML] Cancer stem cell-targeted chimeric antigen receptor (CAR)-T cell therapy: Challenges and prospects
J Masoumi, A Jafarzadeh, J Abdolalizadeh… - … Pharmaceutica Sinica B, 2021 - Elsevier
Cancer stem cells (CSCs) with their self-renewal ability are accepted as cells which initiate
tumors. CSCs are regarded as interesting targets for novel anticancer therapeutic agents …
tumors. CSCs are regarded as interesting targets for novel anticancer therapeutic agents …
Monocytic subclones confer resistance to venetoclax-based therapy in patients with acute myeloid leukemia
S Pei, DA Pollyea, A Gustafson, BM Stevens… - Cancer discovery, 2020 - AACR
Venetoclax-based therapy can induce responses in approximately 70% of older previously
untreated patients with acute myeloid leukemia (AML). However, up-front resistance as well …
untreated patients with acute myeloid leukemia (AML). However, up-front resistance as well …
Anti-human CD117 CAR T-cells efficiently eliminate healthy and malignant CD117-expressing hematopoietic cells
Acute myeloid leukemia (AML) initiating and sustaining cells maintain high cell-surface
similarity with their cells-of-origin, ie, hematopoietic stem and progenitor cells (HSPCs), and …
similarity with their cells-of-origin, ie, hematopoietic stem and progenitor cells (HSPCs), and …
[HTML][HTML] Primitive acute myeloid leukemia cells with long-term proliferative ability in vitro and in vivo lack surface expression of c-kit (CD117)
A Blair, HJ Sutherland - Experimental hematology, 2000 - Elsevier
OBJECTIVE: A hierarchy of progenitor cells is thought to exist in human acute myeloid
leukemia (AML), with only the most primitive cells capable of proliferating to maintain the …
leukemia (AML), with only the most primitive cells capable of proliferating to maintain the …
Cancer stem-like cells in human prostate carcinoma cells DU145: the seeds of the cell line?
C Wei, W Guomin, L Yujun, Q Ruizhe - Cancer biology & therapy, 2007 - Taylor & Francis
The aim of this study is to investigate cancer stem cells and their markers in the prostate
cancer cell line Du145. Different populations of cells were isolated from Du145. The clones …
cancer cell line Du145. Different populations of cells were isolated from Du145. The clones …
Flow cytometry rapidly identifies all acute promyelocytic leukemias with high specificity independent of underlying cytogenetic abnormalities
HY Dong, JX Kung, V Bhardwaj… - American journal of …, 2011 - academic.oup.com
Acute promyelocytic leukemia (APL) is a highly aggressive disease requiring prompt
diagnosis and specific early intervention. Immunophenotyping by flow cytometry (FCM) …
diagnosis and specific early intervention. Immunophenotyping by flow cytometry (FCM) …
Expression of cell-surface antigens in acute promyelocytic leukaemia
E Paietta - Best practice & research Clinical haematology, 2003 - Elsevier
Acute promyelocytic leukaemia (APL) with M3 (or M3v) morphology is the only AML subtype
to date for which morphology and immunophenotype agree. In other words, FAB M3 is …
to date for which morphology and immunophenotype agree. In other words, FAB M3 is …
A surrogate marker profile for PML/RARα expressing acute promyelocytic leukemia and the association of immunophenotypic markers with morphologic and …
E Paietta, O Goloubeva, D Neuberg… - Cytometry Part B …, 2004 - Wiley Online Library
Background The availability of genotype‐specific therapy for PML/RARαpos acute
promyelocytic leukemia (APL) requires that this disease be precisely diagnosed …
promyelocytic leukemia (APL) requires that this disease be precisely diagnosed …
Expression of the stem cell factor receptor C-KIT (CD117) in acute leukemias
C Sperling, S Schwartz, T Buchner, E Thiel… - …, 1997 - haematologica.org
BACKGROUND AND OBJECTIVE: The receptor for stem cell factor (CD117) is the gene
product of the c-kit proto-ontogene. Together with its ligand, the stem cell factor (SCF), it …
product of the c-kit proto-ontogene. Together with its ligand, the stem cell factor (SCF), it …