The use of hypoxia models in cell culture has allowed the characterization of the hypoxia
response at the cellular, biochemical and molecular levels. Although a decrease in oxygen …

Radiation pneumonitis (RP) and radiation fibrosis (RF) are two dose-limiting toxicities of
radiotherapy (RT), especially for lung, and esophageal cancer. It occurs in 5–20% of …

Metastasis is the major cause of death in patients with colorectal carcinoma (CRC). The
most common sites of metastasis are the liver and the peritoneum. Peritoneal …

Abstract Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer
drug target. Many recent studies have provided convincing evidences of strong correlation …

Glioblastoma is the most aggressive form of brain tumor in adults and is characterized by the
presence of hypervascularization and necrosis, both caused by a hypoxic …

The human placenta has a vital role in ensuring a successful pregnancy. Despite the
growing body of knowledge about its cellular compositions and functions, there has been …

Cutaneous wound repair is a highly coordinated cascade of cellular responses to injury
which restores the epidermal integrity and its barrier functions. Even under optimal healing …

Melatonin is a highly evolutionary conserved endogenous molecule that is mainly produced
by the pineal gland, but also by other nonendocrine organs, of most mammals including …

Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis
during embryogenesis, skeletal growth and reproductive functions. VEGF has also been …

The reduction of oxygen to water proceeds via one electron at a time. In the mitochondrial
respiratory chain, Complex IV (cytochrome oxidase) retains all partially reduced …