The use of cobalt chloride as a chemical hypoxia model
J Muñoz‐Sánchez… - Journal of Applied …, 2019 - Wiley Online Library
The use of hypoxia models in cell culture has allowed the characterization of the hypoxia
response at the cellular, biochemical and molecular levels. Although a decrease in oxygen …
response at the cellular, biochemical and molecular levels. Although a decrease in oxygen …
Radiation-induced lung injury (RILI)
L Giuranno, J Ient, D De Ruysscher, MA Vooijs - Frontiers in oncology, 2019 - frontiersin.org
Radiation pneumonitis (RP) and radiation fibrosis (RF) are two dose-limiting toxicities of
radiotherapy (RT), especially for lung, and esophageal cancer. It occurs in 5–20% of …
radiotherapy (RT), especially for lung, and esophageal cancer. It occurs in 5–20% of …
Mechanisms of metastasis in colorectal cancer and metastatic organotropism: hematogenous versus peritoneal spread
E Pretzsch, F Bösch, J Neumann… - Journal of …, 2019 - Wiley Online Library
Metastasis is the major cause of death in patients with colorectal carcinoma (CRC). The
most common sites of metastasis are the liver and the peritoneum. Peritoneal …
most common sites of metastasis are the liver and the peritoneum. Peritoneal …
[HTML][HTML] HIF-1α pathway: role, regulation and intervention for cancer therapy
GN Masoud, W Li - Acta Pharmaceutica Sinica B, 2015 - Elsevier
Abstract Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer
drug target. Many recent studies have provided convincing evidences of strong correlation …
drug target. Many recent studies have provided convincing evidences of strong correlation …
Hypoxia: the cornerstone of glioblastoma
M Domènech, A Hernández, A Plaja… - International journal of …, 2021 - mdpi.com
Glioblastoma is the most aggressive form of brain tumor in adults and is characterized by the
presence of hypervascularization and necrosis, both caused by a hypoxic …
presence of hypervascularization and necrosis, both caused by a hypoxic …
Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy
M Wang, Y Liu, R Sun, F Liu, J Li, L Yan, J Zhang… - Nature Genetics, 2024 - nature.com
The human placenta has a vital role in ensuring a successful pregnancy. Despite the
growing body of knowledge about its cellular compositions and functions, there has been …
growing body of knowledge about its cellular compositions and functions, there has been …
Mesenchymal stromal cells and cutaneous wound healing: a comprehensive review of the background, role, and therapeutic potential
MS Hu, MR Borrelli, HP Lorenz… - Stem cells …, 2018 - Wiley Online Library
Cutaneous wound repair is a highly coordinated cascade of cellular responses to injury
which restores the epidermal integrity and its barrier functions. Even under optimal healing …
which restores the epidermal integrity and its barrier functions. Even under optimal healing …
A review of the molecular aspects of melatonin's anti‐inflammatory actions: recent insights and new perspectives
Melatonin is a highly evolutionary conserved endogenous molecule that is mainly produced
by the pineal gland, but also by other nonendocrine organs, of most mammals including …
by the pineal gland, but also by other nonendocrine organs, of most mammals including …
The biology of VEGF and its receptors
N Ferrara, HP Gerber, J LeCouter - Nature medicine, 2003 - nature.com
Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis
during embryogenesis, skeletal growth and reproductive functions. VEGF has also been …
during embryogenesis, skeletal growth and reproductive functions. VEGF has also been …
Mitochondrial formation of reactive oxygen species
JF Turrens - The Journal of physiology, 2003 - Wiley Online Library
The reduction of oxygen to water proceeds via one electron at a time. In the mitochondrial
respiratory chain, Complex IV (cytochrome oxidase) retains all partially reduced …
respiratory chain, Complex IV (cytochrome oxidase) retains all partially reduced …