The implementation of antiretroviral therapy 23 years ago has rendered HIV infection
clinically manageable. However, the disease remains incurable, since it establishes latent …

Effective antiretroviral therapy (ART) blunts viraemia, which enables HIV-1-infected
individuals to control infection and live long, productive lives. However, HIV-1 infection …

Attempts to reduce the human immunodeficiency virus type 1 (HIV-1) reservoir and induce
antiretroviral therapy (ART)-free virologic control have largely been unsuccessful. In this …

Pharmacologically-induced activation of replication competent proviruses from latency in the
presence of antiretroviral treatment (ART) has been proposed as a step towards curing HIV …

Background Activating the expression of latent virus is an approach that might form part of
an HIV cure. We assessed the ability of the histone deacetylase inhibitor panobinostat to …

Latently infected CD4+ T cells are the main barrier to complete clearance of HIV infection,
but it is unclear what mechanisms govern latent HIV infection in vivo. To address this …

Human immunodeficiency virus (HIV) persistence in latently infected resting memory CD4+
T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important …

Human immunodeficiency virus (HIV) persists indefinitely in individuals with HIV who
receive antiretroviral therapy (ART) owing to a reservoir of latently infected cells that contain …

Reversal of HIV-1 latency by small molecules is a potential cure strategy. This approach will
likely require effective drug combinations to achieve high levels of latency reversal. Using …

Latent reservoirs of HIV-1-infected cells are refractory to antiretroviral therapies (ART) and
remain the major barrier to curing HIV-1. Because latently infected cells are long-lived …