The concept of gap junctions and their role in intercellular communication has been known
for around 50 years. Considerable progress has been made in understanding the …

Articular calcified cartilage (ACC) has been dismissed, by some, as a remnant of
endochondral ossification without functional relevance to joint articulation or weight …

Gap junction intercellular communication (GJIC) allows the transfer of material, message
and energy between cells, which influences cell behaviors including cell proliferation …

Skeletal conditions represent a considerable challenge to health systems globally. Barriers
to effective therapeutic development include a lack of accurate preclinical tissue and …

Bone cells, in particular osteoblasts, are capable of communication with each other during
bone growth and homeostasis. More recently it has become clear that they also …

Cartilage repair has been studied extensively in the context of injury and disease, but the
joint's management of regular sub-injurious damage to cartilage, or 'wear and tear,'which …

Osteoarthritis (OA) is a chronic, progressive, severely debilitating, and multifactorial joint
disease that is recognized as the most common type of arthritis. During the last decade, it …

Articular cartilage has limited healing capacity and no drugs are available that can prevent
or slow the development of osteoarthritis (OA) after joint injury. Mesenchymal stromal cell …

Osteoarthritis (OA) is the most common degenerative joint disease that causes chronic pain
and disability. Different innate immune components, including macrophages, T cells, and …

Gap junction intercellular communication (GJIC) is essential for regulating the development
of the organism and sustaining the internal environmental homeostasis of multi-cellular …