Connexin and gap junctions: perspectives from biology to nanotechnology based therapeutics
S Jindal, S Chockalingam, SS Ghosh… - Translational …, 2021 - Elsevier
The concept of gap junctions and their role in intercellular communication has been known
for around 50 years. Considerable progress has been made in understanding the …
for around 50 years. Considerable progress has been made in understanding the …
Structural clues to articular calcified cartilage function: A descriptive review of this crucial interface tissue
LAE Evans, AA Pitsillides - Journal of anatomy, 2022 - Wiley Online Library
Articular calcified cartilage (ACC) has been dismissed, by some, as a remnant of
endochondral ossification without functional relevance to joint articulation or weight …
endochondral ossification without functional relevance to joint articulation or weight …
IL-10 enhances cell-to-cell communication in chondrocytes via STAT3 signaling pathway
D Guo, S Kan, L Zhang, Z Niu, M Duan, Y Liu, X Pu… - Cellular …, 2023 - Elsevier
Gap junction intercellular communication (GJIC) allows the transfer of material, message
and energy between cells, which influences cell behaviors including cell proliferation …
and energy between cells, which influences cell behaviors including cell proliferation …
Self‐assembling human skeletal organoids for disease modeling and drug testing
DM Abraham, C Herman, L Witek… - … Research Part B …, 2022 - Wiley Online Library
Skeletal conditions represent a considerable challenge to health systems globally. Barriers
to effective therapeutic development include a lack of accurate preclinical tissue and …
to effective therapeutic development include a lack of accurate preclinical tissue and …
Impact of fluid flow shear stress on osteoblast differentiation and cross-talk with articular chondrocytes
Bone cells, in particular osteoblasts, are capable of communication with each other during
bone growth and homeostasis. More recently it has become clear that they also …
bone growth and homeostasis. More recently it has become clear that they also …
Toward defining the role of the synovium in mitigating normal articular cartilage wear and tear
Cartilage repair has been studied extensively in the context of injury and disease, but the
joint's management of regular sub-injurious damage to cartilage, or 'wear and tear,'which …
joint's management of regular sub-injurious damage to cartilage, or 'wear and tear,'which …
Healthy and osteoarthritis-affected joints facing the cellular crosstalk
S Semenistaja, S Skuja, A Kadisa, V Groma - International Journal of …, 2023 - mdpi.com
Osteoarthritis (OA) is a chronic, progressive, severely debilitating, and multifactorial joint
disease that is recognized as the most common type of arthritis. During the last decade, it …
disease that is recognized as the most common type of arthritis. During the last decade, it …
Mesenchymal stromal cells donate mitochondria to articular chondrocytes exposed to mitochondrial, environmental, and mechanical stress
M Fahey, M Bennett, M Thomas, K Montney… - Scientific Reports, 2022 - nature.com
Articular cartilage has limited healing capacity and no drugs are available that can prevent
or slow the development of osteoarthritis (OA) after joint injury. Mesenchymal stromal cell …
or slow the development of osteoarthritis (OA) after joint injury. Mesenchymal stromal cell …
The Importance of Neutrophils in Osteoarthritis: Current Concepts and Therapeutic Perspectives
Osteoarthritis (OA) is the most common degenerative joint disease that causes chronic pain
and disability. Different innate immune components, including macrophages, T cells, and …
and disability. Different innate immune components, including macrophages, T cells, and …
Fibroblast growth factor 8 facilitates cell-cell communication in chondrocytes via p38-MAPK signaling
X Cao, L Cai, D Guo, D Zhang, X Zhou, J Xie - Tissue and Cell, 2023 - Elsevier
Gap junction intercellular communication (GJIC) is essential for regulating the development
of the organism and sustaining the internal environmental homeostasis of multi-cellular …
of the organism and sustaining the internal environmental homeostasis of multi-cellular …