Health data are increasingly being generated at a massive scale, at various levels of
phenotyping and from different types of resources. Concurrent with recent technological …

Abstract Development of cholesteryl ester transfer protein (CETP) inhibitors for coronary
heart disease (CHD) has yet to deliver licensed medicines. To distinguish compound from …

SNP heritability, the proportion of phenotypic variance explained by SNPs, has been
reported for many hundreds of traits. Its estimation requires strong prior assumptions about …

Dysfunction of either the right or left ventricle can lead to heart failure (HF) and subsequent
morbidity and mortality. We performed a genome-wide association study (GWAS) of 16 …

There are currently no disease-modifying treatments for Alzheimer's disease (AD), and an
understanding of preclinical causal biomarkers to help target disease pathogenesis in the …

Liver dysfunction and type 2 diabetes (T2D) are consistently associated. However, it is
currently unknown whether liver dysfunction contributes to, results from, or is merely …

Background Increased circulating plasma urate concentration is associated with an
increased risk of coronary heart disease, but the extent of any causative effect of urate on …

Background: We investigated causal effect of completed growth, measured by adult height,
on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental …

Background Increasing age is the biggest risk factor for dementia, of which Alzheimer's
disease is the commonest cause. The pathological changes underpinning Alzheimer's …

Abstract Interleukin 6 (IL-6) is a multifunctional cytokine with both pro-and anti-inflammatory
properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood …