Deciphering the causal relationship between blood metabolites and Alzheimer's Disease: a Mendelian Randomization study
There are currently no disease modifying treatments for Alzheimer's Disease (AD).
Epidemiological studies have highlighted blood metabolites as potential biomarkers, but …
Epidemiological studies have highlighted blood metabolites as potential biomarkers, but …
Are metabolites linked to midlife cognition on the causal pathway to Alzheimer's Disease? A Mendelian randomization study
There are currently no disease-modifying treatments for Alzheimer's disease (AD), and an
understanding of preclinical causal biomarkers to help target disease pathogenesis in the …
understanding of preclinical causal biomarkers to help target disease pathogenesis in the …
Genetic functional studies of low density lipoprotein-cholesterol (LDL-C) associated variants and the genetic spectrum of familial hypercholesterolemia in different …
RH Fairoozy - 2018 - discovery.ucl.ac.uk
Since the end of the 20th century, cardiovascular disease has been the major cause of
death worldwide. Hypercholesterolemia is major risk factor for CVD. Family-based linkage …
death worldwide. Hypercholesterolemia is major risk factor for CVD. Family-based linkage …
Cholesteryl ester transfer protein as a drug target for cardiovascular disease
AF Schmidt, NB Hunt, M Gordillo-Marañón, P Charoen… - medRxiv, 2020 - medrxiv.org
Drug development of cholesteryl ester transfer protein (CETP) inhibition to prevent coronary
heart disease (CHD) has yet to deliver licensed medicines. To distinguish compound from …
heart disease (CHD) has yet to deliver licensed medicines. To distinguish compound from …
[PDF][PDF] downloaded from Explore Bristol Research, http://research-information. bristol. ac. uk
M Sheikhali Babaei - 2021 - research-information.bris.ac.uk
Background: Genome-wide association studies (GWAS) in Europeans have robustly
associated 111 loci with atrial fibrillation (AF) and 22 loci with stroke risk. However, the …
associated 111 loci with atrial fibrillation (AF) and 22 loci with stroke risk. However, the …
Adiponectina: relação com a distribuição de gordura corporal e influência sobre o risco de doenças cardiovasculares
MC Borges - 2016 - guaiaca.ufpel.edu.br
Adiponectin, a protein produced by mature adipocytes, has its concentration paradoxically
reduced among obese individuals. Animal studies indicate that this protein has insulin …
reduced among obese individuals. Animal studies indicate that this protein has insulin …
[PDF][PDF] Metabolic Characterization of a Rare Genetic Variation within APOC3 and its Lipoprotein Lipase Independent Effects
NJ Timpson - scienceopen.com
Background-Plasma triglyceride levels (TG) have been implicated in atherosclerosis and
coronary heart disease (CHD). Apolipoprotein C-III (APOC3) plays a key role in the …
coronary heart disease (CHD). Apolipoprotein C-III (APOC3) plays a key role in the …
[PDF][PDF] Association of apolipoprotein E gene polymorphisms with blood lipids and their 1 interaction with dietary factors 2
IG Ben-Shlomo, MP Rayman, JA Lovegrove, S Karani - core.ac.uk
Background: Several candidate genes have been identified in relation to lipid 42
metabolism, and among these, lipoprotein lipase (LPL) and apolipoprotein E (APOE) 43 …
metabolism, and among these, lipoprotein lipase (LPL) and apolipoprotein E (APOE) 43 …
[PDF][PDF] only, and not to be further disclosed.
F Drenos, GD Smith, M Ala-Korpela, J Kettunen - cyberleninka.org
Background-Plasma triglyceride levels (TG) have been implicated in atherosclerosis and
coronary heart disease (CHD). Apolipoprotein C-III (APOC3) plays a key role in the …
coronary heart disease (CHD). Apolipoprotein C-III (APOC3) plays a key role in the …
Mendelian randomization: investigating causal relationship between urate and Parkinson's disease
S Burgess - 2018 - repository.cam.ac.uk
Objective: Observational studies have shown that increased plasma urate is associated with
lower risk of Parkinson's Disease (PD), but these studies were not designed to test causality …
lower risk of Parkinson's Disease (PD), but these studies were not designed to test causality …