To increase our understanding of psoriasis, we used high-throughput complementary DNA
sequencing (RNA-seq) to assay the transcriptomes of lesional psoriatic and normal skin. We …

We used the Immunochip array to analyze 2,816 individuals with juvenile idiopathic arthritis
(JIA), comprising the most common subtypes (oligoarticular and rheumatoid factor–negative …

Psoriasis is a chronic, systemic, immune-mediated disease with an incidence of
approximately 2%. The pathogenesis of the disease is complex and not yet fully understood …

Signal Transducer and Activator of Transcription (STAT) 3 has recently emerged as a key
player in the development and pathogenesis of psoriasis and psoriatic-like inflammatory …

Introduction Variation in an individual's response to environmental factors is likely to
influence susceptibility to complex human diseases. The genetic basis of such variation is …

Environmental stimuli are known to contribute to psoriasis pathogenesis and that of other
autoimmune diseases, but the mechanisms are largely unknown. Here we show that the aryl …

Thousands of genetic variants have been identified, which contribute to the development of
complex diseases, but determining how to elucidate their biological consequences for …

Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading
to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation,,. We …

A key challenge in psoriasis therapy is the tendency for lesions to recur in previously
affected anatomical locations after treatment discontinuation following lesion resolution …

Psoriasis vulgaris (PsV) is a common inflammatory and hyperproliferative skin disease. Up
to 30% of people with PsV eventually develop psoriatic arthritis (PsA), an inflammatory …