Extensively drug-resistant tuberculosis is a burgeoning global health crisis mainly affecting
economically active young adults, and has high mortality irrespective of HIV status. In some …

Drug-resistant tuberculosis (DR-TB), including multidrug-resistant TB (MDR-TB) and
extensively drug-resistant TB (XDR-TB), is considered a potential obstacle for elimination of …

Background Patients with highly drug-resistant forms of tuberculosis have limited treatment
options and historically have had poor outcomes. Methods In an open-label, single-group …

Background: The American Thoracic Society, US Centers for Disease Control and
Prevention, European Respiratory Society, and Infectious Diseases Society of America …

Background HIV-infection is associated with increased mortality during multidrug-resistant
tuberculosis treatment, but the extent to which the use of antiretroviral therapy (ART) and anti …

Background Even though the lives of millions have been saved in the past decades, the
mortality rate in patients with drug-resistant tuberculosis is still high. Different factors are …

Background South Africa has a large burden of rifampicin-resistant tuberculosis (RR-TB),
with 18,734 patients diagnosed in 2014. The number of diagnosed patients has increased …

Background In Africa, fewer than half of patients receiving therapy for multidrug-resistant TB
(MDR TB) are successfully treated, with poor outcomes reported for HIV-coinfected patients …

Little is known about the impact of comorbidities on multidrug resistant (MDR) and
extensively drug resistant (XDR) tuberculosis (TB) treatment outcomes. We aimed to …

The global burden of tuberculosis (TB) is still large. The increasing incidence of drug-
resistant, multidrug-resistant (MDR)(resistant to at least rifampicin and isoniazid), and …