Macrophages play an important role in the innate and adaptive immune responses of organ
systems, including the lungs, to particles and pathogens. Cumulative results show that …

Under the concept of" united airway diseases," the airway is a single organ wherein upper
and lower airway diseases are commonly comorbid. The upper and lower airways are lined …

Background The IL-33/ST2 pathway is linked with asthma susceptibility. Inhaled allergens,
pollutants, and respiratory viruses, which trigger asthma exacerbations, induce release of IL …

The response to tumor-initiating inflammatory and genetic insults can vary among
morphologically indistinguishable cells, suggesting as yet uncharacterized roles for …

Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a
murine thymic stromal cell line. TSLP exerts its biological effects by binding to a high-affinity …

Interleukin-33 (IL-33) is a member of the interleukin-1 (IL-1) family that is expressed in the
nuclei of endothelial and epithelial cells of barrier tissues, among others. It functions as an …

The enigmatic eosinophil has emerged as an exciting component of the immune system,
involved in a plethora of homeostatic and inflammatory responses. Substantial progress has …

Lungs are one of the main sites of breast cancer metastasis. The metastatic
microenvironment is essential to facilitate growth of disseminated tumor cells. Cancer …

Interleukin 33 (IL-33) is highly expressed in barrier sites, acting via the suppression of
tumorigenicity 2 receptor (ST2). IL-33/ST2 axis has long been known to play a pivotal role in …

Abstract Interleukin (IL)-33 is a broad-acting alarmin cytokine that can drive inflammatory
responses following tissue damage or infection and is a promising target for treatment of …