Vaccine adjuvants: role and mechanisms of action in vaccine immunogenicity
DJ Marciani - Drug discovery today, 2003 - Elsevier
Inactivated vaccines require adjuvants to stimulate an immune response. The choice of
adjuvant or immune enhancer determines whether the immune response is effective …
adjuvant or immune enhancer determines whether the immune response is effective …
Synthetic agonists of Toll-like receptors 7, 8 and 9
S Agrawal, ER Kandimalla - Biochemical Society Transactions, 2007 - portlandpress.com
TLRs (Toll-like receptors) are a family of innate immune receptors that induce protective
immune responses against infections. Single-stranded viral RNA and bacterial DNA …
immune responses against infections. Single-stranded viral RNA and bacterial DNA …
Immunomodulatory oligonucleotides containing a cytosine-phosphate-2′-deoxy-7-deazaguanosine motif as potent toll-like receptor 9 agonists
ER Kandimalla, L Bhagat, Y Li, D Yu… - Proceedings of the …, 2005 - National Acad Sciences
Bacterial DNA and synthetic oligomers containing CpG dinucleotides activate the immune
system through Toll-like receptor (TLR) 9. Here, we compare the immunostimulatory activity …
system through Toll-like receptor (TLR) 9. Here, we compare the immunostimulatory activity …
Chimeric immunomodulatory compounds and methods of using the same—III
KL Fearon, D Dina, SF Tuck - US Patent 7,785,610, 2010 - Google Patents
WEIKWRHPSBSLNX-UHFFFAOYSA-N [5-(2-amino-6-oxo-3H-purin-9-yl)-3-hydroxyoxolan-2-
yl] methyl [5-(4-amino-2-oxopyrimidin-1-yl)-2-(phosphonooxymethyl) oxolan-3-yl] hydrogen …
yl] methyl [5-(4-amino-2-oxopyrimidin-1-yl)-2-(phosphonooxymethyl) oxolan-3-yl] hydrogen …
Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine …
ER Kandimalla, L Bhagat, D Wang, D Yu… - Nucleic Acids …, 2003 - academic.oup.com
Unmethylated CpG dinucleotides present within certain specific sequence contexts in
bacterial and synthetic DNA stimulate innate immune responses and induce cytokine …
bacterial and synthetic DNA stimulate innate immune responses and induce cytokine …
[PDF][PDF] Recent advances in the development of immunostimulatory oligonucleotides
E Uhlmann, J Vollmer - Current Opinion in Drug Discovery and …, 2003 - researchgate.net
Some immune cells recognize distinct molecular structures present in pathogens through
specific pattern recognition receptors that are able to distinguish prokaryotic DNA from …
specific pattern recognition receptors that are able to distinguish prokaryotic DNA from …
Modifications incorporated in CpG motifs of oligodeoxynucleotides lead to antagonist activity of toll-like receptors 7 and 9
D Yu, D Wang, FG Zhu, L Bhagat, M Dai… - Journal of medicinal …, 2009 - ACS Publications
Oligodeoxynucleotides (ODNs) containing unmethylated CpG dinucleotides act as agonists
of TLR9 and induce Th1-type immune responses. In the present study, we synthesized CpG …
of TLR9 and induce Th1-type immune responses. In the present study, we synthesized CpG …
Overview of laboratory testing and clinical presentations of complement deficiencies and dysregulation
A Frazer-Abel, L Sepiashvili, MM Mbughuni… - Advances in clinical …, 2016 - Elsevier
Historically, complement disorders have been attributed to immunodeficiency associated
with severe or frequent infection. More recently, however, complement has been recognized …
with severe or frequent infection. More recently, however, complement has been recognized …
Immunological and hematological toxicities challenging clinical translation of nucleic acid-based therapeutics
MA Dobrovolskaia, SE McNeil - Expert opinion on biological …, 2015 - Taylor & Francis
Introduction: Nucleic acid-based therapeutics (NATs) are proven agents in correcting
disorders caused by gene mutations, as treatments against cancer, microbes and viruses …
disorders caused by gene mutations, as treatments against cancer, microbes and viruses …
Chemotherapy and chemosensitization of non–small cell lung cancer with a novel immunomodulatory oligonucleotide targeting Toll-like receptor 9
H Wang, ER Rayburn, W Wang, ER Kandimalla… - Molecular cancer …, 2006 - AACR
Lung cancer is a leading cause of death world-wide and the long-term survival rate for lung
cancer patients is one of the lowest for any cancer. New therapies are urgently needed. The …
cancer patients is one of the lowest for any cancer. New therapies are urgently needed. The …