abstract IL-5 is the most potent activator of eosinophils and is produced by Th2 cells and
ILC2s. A role for IL-5 in eosinophil extracellular trap cell death, ie, a proinflammatory cell …

abstract Interleukin (IL)-4 and IL-13, signature type 2 cytokines, exert their actions by binding
to two types of receptors sharing the IL-4R a chain (IL-4Ra). Since IL-4 and IL-13 play …

Background Patients with severe eosinophilic asthma show different responses to various
anti–IL-5 biologics, ranging from super response to nonresponse. Residual disease …

Background Severe Asthma Network in Italy (SANI) is a registry of patients recruited by
accredited centers on severe asthma. Objective To analyze epidemiological, clinical …

Background Chronic rhinosinusitis with nasal polyps (CRSwNP) can be a severe and
debilitating disease associated with significant morbidity, loss of smell, sinus pressure and …

Nasal endoscopy is not only used for the diagnosis of chronic rhinosinusitis with nasal
polyps (CRSwNP), but also for monitoring the response to therapy playing an important role …

Today, chronic rhinosinusitis (CRS) is a symptomatic disease diagnosed by nasal
endoscopy and eventually computed tomography scan, and is treated by pharmacotherapy …

Background The clinical and laboratory features of patients enrolled in the Severe Asthma
Network in Italy (SANI) registry, a web-based observatory collecting demographic, clinical …

Background Chronic rhinosinusitis (CRS) is a heterogeneous, multifactorial inflammatory
disease of the nasal and paranasal mucosa. It has not been possible to date to develop an …

Chronic rhinosinusitis is a chronic inflammatory disease of the upper airways, for which
treatment options include medical or surgical therapy. However, there are limitations to …