The role of microRNAs in neurodegenerative diseases: a review
S Li, Z Lei, T Sun - Cell Biology and Toxicology, 2023 - Springer
MicroRNAs (miRNAs) are non-coding RNAs which are essential post-transcriptional gene
regulators in various neuronal degenerative diseases and playact a key role in these …
regulators in various neuronal degenerative diseases and playact a key role in these …
MicroRNAs in the Onset of Schizophrenia
KT Thomas, SS Zakharenko - Cells, 2021 - mdpi.com
Mounting evidence implicates microRNAs (miRNAs) in the pathology of schizophrenia.
These small noncoding RNAs bind to mRNAs containing complementary sequences and …
These small noncoding RNAs bind to mRNAs containing complementary sequences and …
Single substitution in H3. 3G34 alters DNMT3A recruitment to cause progressive neurodegeneration
Germline histone H3. 3 amino acid substitutions, including H3. 3G34R/V, cause severe
neurodevelopmental syndromes. To understand how these mutations impact brain …
neurodevelopmental syndromes. To understand how these mutations impact brain …
[HTML][HTML] How can we modulate aging through nutrition and physical exercise? An epigenetic approach
Abstract The World Health Organization predicts that by 2050, 2.1 billion people worldwide
will be over 60 years old, a drastic increase from only 1 billion in 2019. Considering these …
will be over 60 years old, a drastic increase from only 1 billion in 2019. Considering these …
The role of microRNAs in neurobiology and pathophysiology of the hippocampus
MicroRNAs (miRNAs) are short non-coding and well-conserved RNAs that are linked to
many aspects of development and disorders. MicroRNAs control the expression of genes …
many aspects of development and disorders. MicroRNAs control the expression of genes …
miR-218 promotes dopaminergic differentiation and controls neuron excitability and neurotransmitter release through the regulation of a synaptic-related genes …
S Pulcrano, R De Gregorio, C De Sanctis… - Journal of …, 2023 - Soc Neuroscience
In the brain, microRNAs (miRNAs) are believed to play a role in orchestrating synaptic
plasticity at a higher level by acting as an additional mechanism of translational regulation …
plasticity at a higher level by acting as an additional mechanism of translational regulation …
DNA methylation regulator-mediated modification patterns and risk of intracranial aneurysm: a multi-omics and epigenome-wide association study integrating machine …
A Maimaiti, M Turhon, A Abulaiti, Y Dilixiati… - Journal of Translational …, 2023 - Springer
Abstract Background Intracranial aneurysms (IAs) pose a significant and intricate challenge.
Elucidating the interplay between DNA methylation and IA pathogenesis is paramount to …
Elucidating the interplay between DNA methylation and IA pathogenesis is paramount to …
[HTML][HTML] Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficits
DC Beard, X Zhang, DY Wu, JR Martin, A Erickson… - Cell reports, 2023 - cell.com
Phenotypic heterogeneity in monogenic neurodevelopmental disorders can arise from
differential severity of variants underlying disease, but how distinct alleles drive variable …
differential severity of variants underlying disease, but how distinct alleles drive variable …
MicroRNA regulation of prefrontal cortex development and psychiatric risk in adolescence
A Morgunova, C Flores - Seminars in cell & developmental biology, 2021 - Elsevier
In this review, we examine the role of microRNAs in the development of the prefrontal cortex
(PFC) in adolescence and in individual differences in vulnerability to mental illness. We …
(PFC) in adolescence and in individual differences in vulnerability to mental illness. We …
AntimiR targeting of microRNA-134 reduces seizures in a mouse model of Angelman syndrome
A Campbell, G Morris, A Sanfeliu, J Augusto… - … Therapy-Nucleic Acids, 2022 - cell.com
Angelman syndrome (AS) is a severe neurodevelopmental disorder featuring ataxia,
cognitive impairment, and drug-resistant epilepsy. AS is caused by mutations or deletion of …
cognitive impairment, and drug-resistant epilepsy. AS is caused by mutations or deletion of …