Abstract Real-world evidence (RWE), the understanding of treatment effectiveness in clinical
practice generated from longitudinal patient-level data from the routine operation of the …

The availability of electronic health records and access to a large number of routine
measurements of serum creatinine and urinary albumin enhance the possibilities for …

In alignment with the International Council of Harmonization's strategic goals, a public-
private consortium has developed a structured template for planning and reporting on the …

Objectives Ambiguity in communication of key study parameters limits the utility of real-world
evidence (RWE) studies in healthcare decision-making. Clear communication about data …

Background: Denosumab is effective for osteoporosis, but discontinuation leads to rapid
reversal of its therapeutic effect. Objective: To estimate the risk for fracture among users of …

Background Renin-angiotensin-system inhibitors (RASi), that include angiotensin converting
enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARBs) reduce proteinuria …

Importance Although tramadol is increasingly used to manage chronic noncancer pain, few
safety studies have compared it with other opioids. Objective To assess the associations of …

Background: Population-scale evidence for the association between dynamic changes in
metabolic syndrome (MetS) status and alterations in the risk for major adverse …

Much has been written about real-world evidence (RWE), a concept that offers an
understanding of the effects of healthcare interventions using routine clinical data. The …

Background Several studies have linked various chronic inflammatory skin diseases
(CISDs) with inflammatory bowel disease (IBD) in a range of data sources with mixed …