Chronic kidney disease (CKD) is a chronic renal dysfunction syndrome that is characterized
by nephron loss, inflammation, myofibroblasts activation, and extracellular matrix (ECM) …

Abstract The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine
fibroblast growth factor (FGF) receptor complexes, as they are required for the high-affinity …

The α-Klotho protein (henceforth denoted Klotho) has antiaging properties, as first observed
in mice homozygous for a hypomorphic Klotho gene (kl/kl). These mice have a shortened …

Loss of Klotho, an anti-aging protein, plays a critical role in the pathogenesis of chronic
kidney diseases. As Klotho is a large transmembrane protein, it is challenging to harness it …

Transforming growth factor-β (TGF-β) is the primary factor that drives fibrosis in most, if not
all, forms of chronic kidney disease (CKD). Inhibition of the TGF-β isoform, TGF-β1, or its …

Klotho has been recognized as a gene involved in the aging process in mammals for over
30 years, where it regulates phosphate homeostasis and the activity of members of the …

TGF-β (transforming growth factor-β) is well identified as a central mediator in renal fibrosis.
TGF-β initiates canonical and non-canonical pathways to exert multiple biological effects …

Chronic kidney disease (CKD) is a major public health issue. At the histological level, renal
fibrosis is the final common pathway of progressive kidney disease irrespective of the initial …

The discovery of the Klotho (KL) gene, which was originally identified as a putative aging-
suppressor gene, has generated tremendous interest and has advanced understanding of …

The metabolically active and perpetually remodeling calcium phosphate–based
endoskeleton in terrestrial vertebrates sets the demands on whole-organism calcium and …