Mechanical allodynia, the perception of innocuous tactile stimulation as painful, is a severe
symptom of chronic pain often produced by damage to peripheral nerves. Allodynia affects …

Objectives: This is a proof-of-concept study to examine whether a chronic, bilateral increase
in insular glutamate can be a causal factor in the development of small fiber neuropathy in …

Radicular pain, a common and complex form of neuropathic pain, presents significant
challenges in treatment. Acupuncture, a therapy originating from ancient traditional Chinese …

Chronic pain and alcohol use disorder (AUD) are highly comorbid, and patients with chronic
pain are more likely to meet the criteria for AUD. Evidence suggests that both conditions …

The insular cortex is an important region of brain involved in the processing of pain and
emotion. Recent studies indicate that lesions in the insular cortex induce pain asymbolia …

This study examined the projections from the rat insular cortex (Ins) to lower brainstem areas
which are possibly involved in orofacial pain processing. We first examined distributions of …

The insular cortex (IC) is associated with important functions linked with pain and emotions.
According to recent reports, neural plasticity in the brain including the IC can be induced by …

Stress affects brain activity and promotes long-term changes in multiple neural systems.
Exposure to stressors causes substantial effects on the perception and response to pain. In …

Central sensitization plays a pivotal role in the maintenance of chronic pain induced by
chronic pancreatitis (CP), but cortical modulation of painful CP remains elusive. This study …

Stimulation of the secondary somatosensory cortex (S2) has attenuated pain in humans and
inflammatory nociception in animals. Here we studied S2 stimulation-induced …