[HTML][HTML] MS2Rescore: data-driven rescoring dramatically boosts immunopeptide identification rates
A Declercq, R Bouwmeester, A Hirschler… - Molecular & Cellular …, 2022 - ASBMB
Immunopeptidomics aims to identify major histocompatibility complex (MHC)-presented
peptides on almost all cells that can be used in anti-cancer vaccine development. However …
peptides on almost all cells that can be used in anti-cancer vaccine development. However …
The D614G mutation in SARS-CoV-2 Spike increases transduction of multiple human cell types
Recently, a novel isolate of the SARS-CoV-2 virus carrying a point mutation in the Spike
protein (D614G) has emerged and rapidly surpassed others in prevalence, including the …
protein (D614G) has emerged and rapidly surpassed others in prevalence, including the …
[HTML][HTML] Single-cell RNA-seq-based proteogenomics identifies glioblastoma-specific transposable elements encoding HLA-I-presented peptides
PE Bonté, YA Arribas, A Merlotti, M Carrascal… - Cell Reports, 2022 - cell.com
We analyze transposable elements (TEs) in glioblastoma (GBM) patients using a
proteogenomic pipeline that combines single-cell transcriptomics, bulk RNA sequencing …
proteogenomic pipeline that combines single-cell transcriptomics, bulk RNA sequencing …
[HTML][HTML] Sequence-based prediction of SARS-CoV-2 vaccine targets using a mass spectrometry-based bioinformatics predictor identifies immunogenic T cell epitopes
Background The ongoing COVID-19 pandemic has created an urgency to identify novel
vaccine targets for protective immunity against SARS-CoV-2. Early reports identify protective …
vaccine targets for protective immunity against SARS-CoV-2. Early reports identify protective …
Glioblastoma evolution and heterogeneity from a 3D whole-tumor perspective
Treatment failure for the lethal brain tumor glioblastoma (GBM) is attributed to intratumoral
heterogeneity and tumor evolution. We utilized 3D neuronavigation during surgical resection …
heterogeneity and tumor evolution. We utilized 3D neuronavigation during surgical resection …
[HTML][HTML] Adoptive immunotherapy beyond CAR T-cells
Simple Summary The aging of the world population leads to a constant increase of cancer-
related morbidity and mortality. Treatment of late-stage tumors has become a significant …
related morbidity and mortality. Treatment of late-stage tumors has become a significant …
Cell-penetrating peptides enhance peptide vaccine accumulation and persistence in lymph nodes to drive immunogenicity
CM Backlund, RL Holden… - Proceedings of the …, 2022 - National Acad Sciences
Peptide-based cancer vaccines are widely investigated in the clinic but exhibit modest
immunogenicity. One approach that has been explored to enhance peptide vaccine potency …
immunogenicity. One approach that has been explored to enhance peptide vaccine potency …
[HTML][HTML] Therapeutic cancer vaccines revamping: technology advancements and pitfalls
Highlights•CVs have been characterized by positive safety and immunogenicity profiles but
low levels of clinical efficacy.•Novel CV strategies entail personalized formulations and …
low levels of clinical efficacy.•Novel CV strategies entail personalized formulations and …
A machine learning model for ranking candidate HLA class I neoantigens based on known neoepitopes from multiple human tumor types
Tumor neoepitopes presented by major histocompatibility complex (MHC) class I are
recognized by tumor-infiltrating lymphocytes (TIL) and are targeted by adoptive T-cell …
recognized by tumor-infiltrating lymphocytes (TIL) and are targeted by adoptive T-cell …
[HTML][HTML] SARS-CoV-2 escape from cytotoxic T cells during long-term COVID-19
OV Stanevich, EI Alekseeva, M Sergeeva… - Nature …, 2023 - nature.com
Evolution of SARS-CoV-2 in immunocompromised hosts may result in novel variants with
changed properties. While escape from humoral immunity certainly contributes to intra-host …
changed properties. While escape from humoral immunity certainly contributes to intra-host …