Accurate MHC motif deconvolution of immunopeptidomics data reveals a significant contribution of DRB3, 4 and 5 to the total DR immunopeptidome
Mass spectrometry (MS) based immunopeptidomics is used in several biomedical
applications including neo-epitope discovery in oncology, next-generation vaccine …
applications including neo-epitope discovery in oncology, next-generation vaccine …
Oktoberfest: Open‐source spectral library generation and rescoring pipeline based on Prosit
Abstract Machine learning (ML) and deep learning (DL) models for peptide property
prediction such as Prosit have enabled the creation of high quality in silico reference …
prediction such as Prosit have enabled the creation of high quality in silico reference …
Identification and validation of 174 COVID-19 vaccine candidate epitopes reveals low performance of common epitope prediction tools
M Prachar, S Justesen, DB Steen-Jensen… - Scientific reports, 2020 - nature.com
The outbreak of SARS-CoV-2 (2019-nCoV) virus has highlighted the need for fast and
efficacious vaccine development. Stimulation of a proper immune response that leads to …
efficacious vaccine development. Stimulation of a proper immune response that leads to …
Identification of presented SARS-CoV-2 HLA class I and HLA class II peptides using HLA peptidomics
A Nagler, S Kalaora, C Barbolin, A Gangaev… - Cell Reports, 2021 - cell.com
The human leukocyte antigen (HLA)-bound viral antigens serve as an immunological
signature that can be selectively recognized by T cells. As viruses evolve by acquiring …
signature that can be selectively recognized by T cells. As viruses evolve by acquiring …
IEAtlas: an atlas of HLA-presented immune epitopes derived from non-coding regions
Y Cai, D Lv, D Li, J Yin, Y Ma, Y Luo, L Fu… - Nucleic acids …, 2023 - academic.oup.com
Cancer-related epitopes can engage the immune system against tumor cells, thus exploring
epitopes derived from non-coding regions is emerging as a fascinating field in cancer …
epitopes derived from non-coding regions is emerging as a fascinating field in cancer …
MR1 antigen presentation to MAIT cells and other MR1-restricted T cells
HEG McWilliam, JA Villadangos - Nature Reviews Immunology, 2024 - nature.com
MHC antigen presentation plays a fundamental role in adaptive and semi-invariant T cell
immunity. Distinct MHC molecules bind antigens that differ in chemical structure, origin and …
immunity. Distinct MHC molecules bind antigens that differ in chemical structure, origin and …
Progress identifying and analyzing the human proteome: 2021 metrics from the HUPO human proteome project
The 2021 Metrics of the HUPO Human Proteome Project (HPP) show that protein expression
has now been credibly detected (neXtProt PE1 level) for 18 357 (92.8%) of the 19 778 …
has now been credibly detected (neXtProt PE1 level) for 18 357 (92.8%) of the 19 778 …
Challenges and solutions for therapeutic TCR‐based agents
Recent development of methods to discover and engineer therapeutic T‐cell receptors
(TCRs) or antibody mimics of TCRs, and to understand their immunology and …
(TCRs) or antibody mimics of TCRs, and to understand their immunology and …
Individual HLA heterogeneity and its implications for cellular immune evasion in cancer and beyond
S Pagliuca, C Gurnari, MT Rubio, V Visconte… - Frontiers in …, 2022 - frontiersin.org
Structural and functional variability of human leukocyte antigen (HLA) is the foundation for
competent adaptive immune responses against pathogen and tumor antigens as it assures …
competent adaptive immune responses against pathogen and tumor antigens as it assures …
Artificial Intelligence in Oncology: Current Landscape, Challenges, and Future Directions
Artificial intelligence (AI) in oncology is advancing beyond algorithm development to
integration into clinical practice. This review describes the current state of the field, with a …
integration into clinical practice. This review describes the current state of the field, with a …