Genetic studies associate killer cell immunoglobulin-like receptors (KIRs) and their HLA
class I ligands with a variety of human diseases. The basis for these associations and the …

Cancer immunotherapy is a method of controlling and eliminating tumors by reactivating the
body's cancer-immunity cycle and restoring its antitumor immune response. The increased …

Identification of CD8+ T cell epitopes is critical for the development of immunotherapeutics.
Existing methods for major histocompatibility complex class I (MHC class I) ligand discovery …

Cancer transcriptomes frequently exhibit RNA dysregulation. As the resulting aberrant
transcripts may be translated into cancer-specific proteins, there is growing interest in …

The development of vaccines, which prime the immune system to respond to future
infections, has led to global declines in morbidity and mortality from dreadful infectious …

Abstract The SysteMHC Atlas v1. 0 was the first public repository dedicated to mass
spectrometry-based immunopeptidomics. Here we introduce a newly released version of the …

The identification of major histocompatibility complex (MHC)‐binding peptides in mass
spectrometry (MS)‐based immunopeptideomics relies largely on database search engines …

Over the past two decades, significant technological innovations have led to messenger
RNA (mRNA) becoming a promising option for developing prophylactic and therapeutic …

Cancer immunotherapy has dramatically changed the approach to cancer treatment. The
aim of targeting the immune system to recognize and destroy cancer cells has afforded …

The identification of T-cell epitopes is key for a complete molecular understanding of
immune recognition mechanisms in infectious diseases, autoimmunity and cancer. T-cell …