The identification of T-cell epitopes is key for a complete molecular understanding of
immune recognition mechanisms in infectious diseases, autoimmunity and cancer. T-cell …

Engineered T cell receptor T (TCR-T) cell therapy has facilitated the generation of
increasingly reliable tumor antigen-specific adaptable cellular products for the treatment of …

Introduction The field of cancer therapy has undergone a major transformation in less than a
decade due to the introduction of checkpoint inhibitors, the advent of next generation …

Therapeutic cancer vaccination seeks to elicit activation of tumor-reactive T cells capable of
recognizing tumor-associated antigens (TAA) and eradicating malignant cells. Here, we …

Malignant melanoma is the leading cause of death among cutaneous malignancies. While
its incidence is increasing, the most recent cancer statistics show a small but clear decrease …

Cancers avoid immune surveillance through an array of mechanisms, including perturbation
of HLA class I antigen presentation. Merkel cell carcinoma (MCC) is an aggressive, HLA-I …

Hereditary cancer syndromes (HCS) account for 5~ 10% of all cancer diagnosis. Lynch
syndrome (LS) is one of the most common HCS, caused by germline mutations in the DNA …

T-cell recognition of somatic mutation-derived cancer neoepitopes can lead to tumor
regression. Due to the difficulty to identify effective neoepitopes, constructing a database for …

CD4+ helper T cells contribute important functions to the immune response during pathogen
infection and tumor formation by recognizing antigenic peptides presented by class II major …

Central to successful cancer immunotherapy is effective T cell antitumor immunity. Multiple
targeted immunotherapies engineered to invigorate T cell-driven antitumor immunity rely on …