The biological and clinical significance of emerging SARS-CoV-2 variants
The past several months have witnessed the emergence of SARS-CoV-2 variants with novel
spike protein mutations that are influencing the epidemiological and clinical aspects of the …
spike protein mutations that are influencing the epidemiological and clinical aspects of the …
The impact of pre-existing cross-reactive immunity on SARS-CoV-2 infection and vaccine responses
Pre-existing cross-reactive immune responses to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) proteins in infection-naive subjects have been described by …
coronavirus 2 (SARS-CoV-2) proteins in infection-naive subjects have been described by …
Distinguishing features of Long COVID identified through immune profiling
Post-acute infection syndromes may develop after acute viral disease. Infection with SARS-
CoV-2 can result in the development of a post-acute infection syndrome known as long …
CoV-2 can result in the development of a post-acute infection syndrome known as long …
Broadly neutralizing antibodies target the coronavirus fusion peptide
The potential for future coronavirus outbreaks highlights the need to broadly target this
group of pathogens. We used an epitope-agnostic approach to identify six monoclonal …
group of pathogens. We used an epitope-agnostic approach to identify six monoclonal …
Broad betacoronavirus neutralization by a stem helix–specific human antibody
The spillovers of betacoronaviruses in humans and the emergence of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) variants highlight the need for broad …
respiratory syndrome coronavirus 2 (SARS-CoV-2) variants highlight the need for broad …
Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity
INTRODUCTION A systematic characterization of the humoral response to severe acute
respiratory system coronavirus 2 (SARS-CoV-2) epitopes has yet to be performed. This …
respiratory system coronavirus 2 (SARS-CoV-2) epitopes has yet to be performed. This …
Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination
INTRODUCTION The clinical manifestations of COVID-19 vary from asymptomatic infection
to respiratory failure. Severe disease courses are primarily associated with advanced age …
to respiratory failure. Severe disease courses are primarily associated with advanced age …
Cross-reactive serum and memory B-cell responses to spike protein in SARS-CoV-2 and endemic coronavirus infection
Pre-existing immunity to seasonal endemic coronaviruses could have profound
consequences for antibody responses to SARS-CoV-2, induced from natural infection or …
consequences for antibody responses to SARS-CoV-2, induced from natural infection or …
A comparison of four serological assays for detecting anti–SARS-CoV-2 antibodies in human serum samples from different populations
L Grzelak, S Temmam, C Planchais… - Science translational …, 2020 - science.org
It is of paramount importance to evaluate the prevalence of both asymptomatic and
symptomatic cases of SARS-CoV-2 infection and their differing antibody response profiles …
symptomatic cases of SARS-CoV-2 infection and their differing antibody response profiles …
ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies
The coronavirus spike glycoprotein attaches to host receptors and mediates viral fusion.
Using a broad screening approach, we isolated seven monoclonal antibodies (mAbs) that …
Using a broad screening approach, we isolated seven monoclonal antibodies (mAbs) that …