The interaction over time of genetic, epigenetic and environmental factors (ie, autoimmune
ecology) increases or decreases the liability an individual would have to develop an …

Systemic lupus erythematosus (SLE) is a chronic multi-organ debilitating autoimmune
disease, which mainly afflicts women in the reproductive years. A complex interaction of …

Interferon γ (IFNγ) is a pleiotropic protein secreted by immune cells. IFNγ signals through the
IFNγ receptor, a protein complex that mediates downstream signaling events. Studies into …

Signal transducer and activator of transcription 4 (STAT4) is a member of the STAT family
and localizes to the cytoplasm. STAT4 is phosphorylated after a variety of cytokines bind to …

Objective We investigated the mechanistic and pharmacological properties of anifrolumab, a
fully human, effector-null, anti-type I interferon (IFN) alpha receptor 1 (IFNAR1) monoclonal …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease, and CD4+ T cells
are known to promote SLE development. Here, we explore heterogeneities in the CD4+ T …

The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway
is an evolutionarily conserved mechanism of transmembrane signal transduction that …

Resolvin D1 (RvD1) prompts inflammation resolution and regulates immune responses. We
explored the effect of RvD1 on systemic lupus erythematosus (SLE) and investigated the …

The Janus kinase (JAK)/signal transducers and activators of transcription (STAT) pathway is
an important intracellular route through which many different extracellular soluble …

Despite increasing evidence that long non-coding RNAs (lncRNAs) widely take part in
human diseases, the role of lncRNAs in systemic lupus erythematosus (SLE) is largely …