The alphaviruses: gene expression, replication, and evolution
JH Strauss, EG Strauss - Microbiological reviews, 1994 - Am Soc Microbiol
The alphaviruses are a genus of 26 enveloped viruses that cause disease in humans and
domestic animals. Mosquitoes or other hematophagous arthropods serve as vectors for …
domestic animals. Mosquitoes or other hematophagous arthropods serve as vectors for …
Alphavirus-based expression vectors: strategies and applications.
I Frolov, TA Hoffman, BM Prágai… - Proceedings of the …, 1996 - National Acad Sciences
Alphaviruses are positive-strand RNA viruses that can mediate efficient cytoplasmic gene
expression in insect and vertebrate cells. Through recombinant DNA technology, the …
expression in insect and vertebrate cells. Through recombinant DNA technology, the …
Bioinspired engineering of fusogen and targeting moiety equipped nanovesicles
Cell-derived small extracellular vesicles have been exploited as potent drug vehicles.
However, significant challenges hamper their clinical translation, including inefficient …
However, significant challenges hamper their clinical translation, including inefficient …
Structural changes of envelope proteins during alphavirus fusion
Alphaviruses are enveloped RNA viruses that have a diameter of about 700 Å and can be
lethal human pathogens. Entry of virus into host cells by endocytosis is controlled by two …
lethal human pathogens. Entry of virus into host cells by endocytosis is controlled by two …
Formation and intracellular localization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia and Sindbis viruses
J Dubuisson, HH Hsu, RC Cheung… - Journal of …, 1994 - Am Soc Microbiol
Hepatitis C virus (HCV) encodes two putative virion glycoproteins (E1 and E2) which are
released from the polyprotein by signal peptidase cleavage. In this report, we have …
released from the polyprotein by signal peptidase cleavage. In this report, we have …
Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization
S Sun, Y Xiang, W Akahata, H Holdaway, P Pal… - Elife, 2013 - elifesciences.org
A 5.3 Å resolution, cryo-electron microscopy (cryoEM) map of Chikungunya virus-like
particles (VLPs) has been interpreted using the previously published crystal structure of the …
particles (VLPs) has been interpreted using the previously published crystal structure of the …
The enigmatic alphavirus non-structural protein 3 (nsP3) revealing its secrets at last
B Götte, L Liu, GM McInerney - Viruses, 2018 - mdpi.com
Alphaviruses encode 4 non-structural proteins (nsPs), most of which have well-understood
functions in capping and membrane association (nsP1), polyprotein processing and RNA …
functions in capping and membrane association (nsP1), polyprotein processing and RNA …
Alphavirus vectors and vaccination
JO Rayner, SA Dryga, KI Kamrud - Reviews in medical virology, 2002 - Wiley Online Library
Alphaviruses are positive‐stranded RNA viruses that have a broad host range and therefore
are capable of replicating in many vertebrate and invertebrate cells. The single‐stranded …
are capable of replicating in many vertebrate and invertebrate cells. The single‐stranded …
Cryo-electron microscopy reveals the functional organization of an enveloped virus, Semliki Forest virus
Semliki Forest virus serves as a paradigm for membrane fusion and assembly. Our
icosahedral reconstruction combined 5276 particle images from 48 cryo-electron …
icosahedral reconstruction combined 5276 particle images from 48 cryo-electron …
Locations of carbohydrate sites on alphavirus glycoproteins show that E1 forms an icosahedral scaffold
SV Pletnev, W Zhang, S Mukhopadhyay, BR Fisher… - Cell, 2001 - cell.com
There are 80 spikes on the surface of Sindbis virus arranged as an icosahedral surface
lattice. Each spike consists of three copies of each of the glycoproteins E1 and E2. There are …
lattice. Each spike consists of three copies of each of the glycoproteins E1 and E2. There are …