Hexanucleotide expansion in an intron of the C9orf72 gene causes amyotrophic lateral
sclerosis and frontotemporal dementia. However, beyond bioinformatics predictions that …

Frontotemporal lobar degeneration (FTLD) is a heterogeneous group of disorders
characterized by disturbances of behavior and personality and different types of language …

We assessed the geographical distribution of C9orf72 G 4 C 2 expansions in a pan‐E
uropean frontotemporal lobar degeneration (FTLD) cohort (n= 1,205), ascertained by the E …

Genetic analysis revealed the hexanucleotide repeat expansion GGGGCC within the
regulatory region of the gene C9orf72 as the most common cause of familial amyotrophic …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are part of a
disease spectrum associated with TDP-43 pathology. Strong evidence supporting this is the …

There is increasing evidence that frontotemporal dementia and amyotrophic lateral sclerosis
are part of a disease continuum. Recently, a hexanucleotide repeat expansion in C9orf72 …

Our understanding of amyotrophic lateral sclerosis and frontotemporal dementia has
advanced dramatically since the discovery of cytoplasmic TAR DNA-binding protein 43 (TDP …

Objective: To assess the genetic contribution of TBK1, a gene implicated in amyotrophic
lateral sclerosis (ALS), frontotemporal dementia (FTD), and FTD-ALS, in Belgian FTD and …

Background It has been well established that the TMEM106B gene rs1990622 variant was a
frontotemporal dementia (FTD) risk factor. Until recently, growing evidence highlights the …

The hexanucleotide repeat expansion (HRE) in the C9ORF72 gene is the main cause of two
tightly linked neurodegenerative diseases, amyotrophic lateral sclerosis (ALS) and …