Nitrogen containing heterocycles as anticancer agents: a medicinal chemistry perspective

A Kumar, AK Singh, H Singh, V Vijayan, D Kumar… - Pharmaceuticals, 2023 - mdpi.com
Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …

Quinolines, a perpetual, multipurpose scaffold in medicinal chemistry

P Yadav, K Shah - Bioorganic Chemistry, 2021 - Elsevier
Quinoline is a versatile pharmacophore, a privileged scaffold and an outstanding fused
heterocyclic compound with a wide range of pharmacological prospective such as …

Recent advances in the synthesis of biologically and pharmaceutically active quinoline and its analogues: a review

A Weyesa, E Mulugeta - RSC advances, 2020 - pubs.rsc.org
Recently, quinoline has become an essential heterocyclic compound due to its versatile
applications in the fields of industrial and synthetic organic chemistry. It is a vital scaffold for …

The biological activity of natural alkaloids against herbivores, cancerous cells and pathogens

A Thawabteh, S Juma, M Bader, D Karaman, L Scrano… - Toxins, 2019 - mdpi.com
The growing incidence of microorganisms that resist antimicrobials is a constant concern for
the scientific community, while the development of new antimicrobials from new chemical …

Green recipes to quinoline: A review

LM Nainwal, S Tasneem, W Akhtar, G Verma… - European Journal of …, 2019 - Elsevier
The quinoline core possesses a vast number of biological activities such as anticancer,
antimalarial, antimicrobial, antifungal, antitubercular and antileishmanial. The conventional …

Novel structural hybrids of quinoline and thiazole moieties: Synthesis and evaluation of antibacterial and antifungal activities with molecular modeling studies

SI Eissa, AM Farrag, SY Abbas, MF El Shehry… - Bioorganic …, 2021 - Elsevier
One of the best ways to design new biocidal agents is synthesizing hybrid molecules by
combining two or more bioactive moieties in a single molecular scaffold. So, new series of …

Seeking heterocyclic scaffolds as antivirals against dengue virus

S De, B Aamna, R Sahu, S Parida, SK Behera… - European Journal of …, 2022 - Elsevier
Dengue is one of the most typical viral infection categorized in the Neglected Tropical
Diseases (NTDs). It is transmitted via the female Aedes aegypti mosquito to humans and …

Computational investigation of bioactive 2, 3-diaryl quinolines using DFT method: FT-IR, NMR spectra, NBO, NLO, HOMO-LUMO transitions, and quantum-chemical …

S Janeoo, A Saroa, R Kumar, H Kaur - Journal of Molecular Structure, 2022 - Elsevier
Quinoline derivatives are widely utilized in a variety of applications, including medicine and
materials. In this work our previously developed bioactive fluorine-containing 2, 3 …

Synthetic and medicinal perspective of quinolines as antiviral agents

R Kaur, K Kumar - European Journal of Medicinal Chemistry, 2021 - Elsevier
In current scenario, various heterocycles have come up exhibiting crucial role in various
medicinal agents which are valuable for mankind. Out of diverse range of heterocycle …

Quinoline‐derivatives as privileged scaffolds for medicinal and pharmaceutical chemists: A comprehensive review

V Yadav, J Reang, V Sharma, J Majeed… - Chemical Biology & …, 2022 - Wiley Online Library
The quinoline scaffolds are privileged for their numerous biological activities in the
pharmaceutical field. This moiety constitutes a well‐known space in several marketed …