Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

Kidney cells and tissues derived from human pluripotent stem cells (hPSCs) may enable
organ regeneration, disease modeling and drug screening. We report an efficient …

Organoids—Preclinical Models of Disease An organoid is a three-dimensional construct
composed of multiple cell types that originates from stem cells through self-organization and …

Abstract Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important
potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute …

Summary Recapitulating three-dimensional (3D) structures of complex organs, such as the
kidney, from pluripotent stem cells (PSCs) is a major challenge. Here, we define the …

With the prevalence of end-stage renal disease rising 8% per annum globally, there is an
urgent need for renal regenerative strategies. The kidney is a mesodermal organ that …

Kidney organoids are regarded as important tools with which to study the development of
the normal and diseased human kidney. Since the first reports of human pluripotent stem …

The primary causes of chronic kidney disease (CKD) in children differ from those of CKD in
adults. In the USA the most common diagnostic groups of renal disease that manifest before …

Kidney organoids made from pluripotent stem cells have the potential to revolutionize how
kidney development, disease, and injury are studied. Current protocols are technically …