Cardiac energy metabolism in heart failure
Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …
the energy metabolic changes that occur in heart failure are complex and are dependent not …
PPAR control of metabolism and cardiovascular functions
D Montaigne, L Butruille, B Staels - Nature Reviews Cardiology, 2021 - nature.com
Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription
factors that regulate gene expression following ligand activation. PPARα increases cellular …
factors that regulate gene expression following ligand activation. PPARα increases cellular …
The role of peroxisome proliferator-activated receptors (PPAR) in immune responses
Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription
factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently …
factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently …
Myocardial fatty acid metabolism in health and disease
There is a constant high demand for energy to sustain the continuous contractile activity of
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …
Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy
Heart disease is a leading cause of death worldwide. In many forms of heart disease,
including heart failure, ischaemic heart disease and diabetic cardiomyopathies, changes in …
including heart failure, ischaemic heart disease and diabetic cardiomyopathies, changes in …
Sorting out the roles of PPARα in energy metabolism and vascular homeostasis
P Lefebvre, G Chinetti, JC Fruchart… - The Journal of clinical …, 2006 - Am Soc Clin Investig
PPARα is a nuclear receptor that regulates liver and skeletal muscle lipid metabolism as
well as glucose homeostasis. Acting as a molecular sensor of endogenous fatty acids (FAs) …
well as glucose homeostasis. Acting as a molecular sensor of endogenous fatty acids (FAs) …
[HTML][HTML] Targeting fatty acid and carbohydrate oxidation—a novel therapeutic intervention in the ischemic and failing heart
Cardiac ischemia and its consequences including heart failure, which itself has emerged as
the leading cause of morbidity and mortality in developed countries are accompanied by …
the leading cause of morbidity and mortality in developed countries are accompanied by …
[HTML][HTML] Abnormalities of glucose and lipid metabolism in myocardial ischemia-reperfusion injury
H Tian, X Zhao, Y Zhang, Z Xia - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Myocardial ischemia-reperfusion injury is a common condition in cardiovascular diseases,
and the mechanism of its occurrence involves multiple complex metabolic pathways and …
and the mechanism of its occurrence involves multiple complex metabolic pathways and …
Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells
N Marx, H Duez, JC Fruchart, B Staels - Circulation research, 2004 - Am Heart Assoc
A large body of data gathered over the past couple of years has identified the peroxisome
proliferator-activated receptors (PPAR) α, γ, and β/δ as transcription factors exerting …
proliferator-activated receptors (PPAR) α, γ, and β/δ as transcription factors exerting …