Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription
factors that regulate gene expression following ligand activation. PPARα increases cellular …

Peroxisome proliferator-activated receptors (PPARs) are fatty acid-activated transcription
factors of nuclear hormone receptor superfamily that regulate energy metabolism. Currently …

The heart consumes large amounts of energy in the form of ATP that is continuously
replenished by oxidative phosphorylation in mitochondria and, to a lesser extent, by …

There is a constant high demand for energy to sustain the continuous contractile activity of
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …

Heart disease is a leading cause of death worldwide. In many forms of heart disease,
including heart failure, ischaemic heart disease and diabetic cardiomyopathies, changes in …

PPARα is a nuclear receptor that regulates liver and skeletal muscle lipid metabolism as
well as glucose homeostasis. Acting as a molecular sensor of endogenous fatty acids (FAs) …

Cardiac ischemia and its consequences including heart failure, which itself has emerged as
the leading cause of morbidity and mortality in developed countries are accompanied by …

Myocardial ischemia-reperfusion injury is a common condition in cardiovascular diseases,
and the mechanism of its occurrence involves multiple complex metabolic pathways and …

A large body of data gathered over the past couple of years has identified the peroxisome
proliferator-activated receptors (PPAR) α, γ, and β/δ as transcription factors exerting …