Cryptococcus neoformans: the yeast that likes it hot

JR Perfect - FEMS yeast research, 2006 - academic.oup.com
The ability of fungi to grow well at mammalian body temperatures is a fundamental
characteristic of invasive human fungal pathogens. Cryptococcus neoformans, with its …

[HTML][HTML] Animal models of Cryptococcus neoformans in identifying immune parameters associated with primary infection and reactivation of latent infection

TG Normile, AM Bryan, M Del Poeta - Frontiers in Immunology, 2020 - frontiersin.org
Cryptococcus species are environmental fungal pathogens and the causative agents of
cryptococcosis. Infection occurs upon inhalation of infectious particles, which proliferate in …

Protection against Cryptococcosis by Using a Murine Gamma Interferon-Producing Cryptococcus neoformans Strain

FL Wormley Jr, JR Perfect, C Steele… - Infection and …, 2007 - Am Soc Microbiol
We evaluated cell-mediated immune (CMI) responses in mice given a pulmonary infection
with a Cryptococcus neoformans strain engineered to produce the Th1-type cytokine gamma …

The Link between Morphotype Transition and Virulence in Cryptococcus neoformans

L Wang, B Zhai, X Lin - PLoS pathogens, 2012 - journals.plos.org
Cryptococcus neoformans is a ubiquitous human fungal pathogen. This pathogen can
undergo morphotype transition between the yeast and the filamentous form and such …

Cryptococcus gattii isolates from the British Columbia cryptococcosis outbreak induce less protective inflammation in a murine model of infection than Cryptococcus …

PY Cheng, A Sham, JW Kronstad - Infection and immunity, 2009 - Am Soc Microbiol
The fungal pathogen Cryptococcus neoformans causes approximately one million cases of
cryptococcosis per year in people with AIDS. In contrast, the related species C. gattii is …

Mechanisms of cryptococcal virulence and persistence

MA Olszewski, Y Zhang, GB Huffnagle - Future microbiology, 2010 - Future Medicine
Cryptococcus neoformans is an environmental yeast that is a leading cause of fatal mycosis
in AIDS patients and a major cause of meningoencephalitis and CNS-related mortality …

A call to arms: quest for a cryptococcal vaccine

MCC Van Dyke, FL Wormley - Trends in microbiology, 2018 - cell.com
Cryptococcosis remains a significant cause of morbidity and mortality world-wide,
particularly among AIDS patients. Yet, to date, there are no licensed vaccines clinically …

A Decade of Experience: Cryptococcus gattii in British Columbia

KH Bartlett, PY Cheng, C Duncan, E Galanis, L Hoang… - Mycopathologia, 2012 - Springer
It has been over a decade since Cryptococcus gattii was first recognized as the causative
organism of an outbreak of cryptococcosis on Vancouver Island, British Columbia. A number …

Vaccines and protective immune memory against cryptococcosis

K Ueno, N Yanagihara, K Shimizu… - Biological and …, 2020 - jstage.jst.go.jp
Cryptococcosis is a potentially lethal disease caused by fungal pathogens including
Cryptococcus neoformans and Cryptococcus gattii species complex. These fungal …

Development of protective inflammation and cell-mediated immunity against Cryptococcus neoformans after exposure to hyphal mutants

B Zhai, KL Wozniak, J Masso-Silva, S Upadhyay… - MBio, 2015 - Am Soc Microbiol
Morphological switch is tightly coupled with the pathogenesis of many dimorphic fungal
pathogens. Cryptococcus neoformans, the major causative agent of cryptococcal meningitis …