Although many kinds of therapies are applied in the clinic, drug-resistance is a major and
unavoidable problem. Another disturbing statistic is the limited number of drug targets, which …

Propolis is a natural material that honey bees (Apis mellifera) produce from various
botanical sources. The therapeutic activity of propolis, including antibacterial, antifungal, and …

Gasdermins are a family of structurally related proteins originally described for their role in
pyroptosis. Gasdermin B (GSDMB) is currently the least studied, and while its association …

Proteolysis targeting chimera (PROTAC), hijacking protein of interest (POI) and recruiting E3
ligase for target degradation via the ubiquitin-proteasome pathway, is a novel drug …

Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is overexpressed
and activated in several advanced-stage solid cancers. FAK promotes tumour progression …

The CB 1 and CB 2 cannabinoid receptors (CB 1 R, CB 2 R) are members of the G protein-
coupled receptor (GPCR) family that were identified over 20 years ago. CB 1 Rs and CB 2 …

Enzymatic inhibition has proven to be a successful modality for the development of many
small-molecule drugs. In recent years, small-molecule-induced protein degradation has …

The blood-testis barrier (BTB) is one of the tightest blood-tissue barriers in the mammalian
body. It divides the seminiferous epithelium into the basal and the apical (adluminal) …

Focal adhesion kinase (FAK) is a key regulator of growth factor receptor-and integrin-
mediated signals, governing fundamental processes in normal and cancer cells through its …

There is currently an unmet need for the supply of autologous, patient-specific stem cells for
regenerative therapies in the clinic. Mesenchymal stem cell differentiation can be driven by …