Advanced prostate cancer is frequently accompanied by the development of metastasis to
bone. In the past, prostate cancer bone metastases were characterized as being …

A considerable amount of research time has been invested in studies aimed at elucidating
pathogenic processes in systemic sclerosis (SSc). Despite this, major challenges for …

Although milk yield of cows and goats is known to be closely related to the total flow of blood
through the udder, a number of studies suggest that milk yield can vary independently. No …

Hepatorenal syndrome (HRS) is a serious complication of liver cirrhosis with critically poor
prognosis. The pathophysiological hallmark is severe renal vasoconstriction, resulting from …

Aging is the most critical risk factor for the development of cardiovascular diseases and their
complications. Therefore, the fine-tuning of cellular response to getting older is an essential …

Objective To determine the time course of big-endothelin (big-ET) and its relationship to
proinflammatory cytokines and organ function in sepsis. Design Prospective analysis in …

Pulmonary hypertension (PH) is an incurable, chronic disease of small pulmonary vessels.
Progressive remodeling of the pulmonary vasculature results in increased pulmonary …

Abstract Endothelin-1 (ET-1) is a 21-amino acid polypeptide produced primarily by vascular
endothelial cells. First discovered in 1988 as a potent vasoconstrictor, it has subsequently …

Regular resistance exercise is associated with metabolic, neuromuscular and
cardiovascular adaptations which improve quality of life and health. However, sedentary …

Subarachnoid hemorrhage (SAH) is a common cerebrovascular disease with high mortality
and disability rates. Despite progressive advances in drugs and surgical techniques …