Menopause is the final step in the process referred to as ovarian ageing. The age related
decrease in follicle numbers dictates the onset of cycle irregularity and the final cessation of …

Theca cells function in a diverse range of necessary roles during folliculogenesis; to
synthesize androgens, provide crosstalk with granulosa cells and oocytes during …

There is now evidence that oestrogens and androgens can influence male and female
reproductive systems. In order to accurately identify the sites of action of oestrogens and …

The production of fertile eggs with the capacity to develop into larvae and subsequently into
marketable fish is centrally important to the aquaculture industry. This entails not only the …

The female germline comprises a reserve population of primordial (non-growing) follicles
containing diplotene oocytes arrested in the first meiotic prophase. By convention, the …

Primordial follicle formation and the subsequent transition of follicles to the primary and
secondary stages encompass the early events during folliculogenesis in mammals. These …

Fertility counseling should be offered to all individuals of young reproductive age early in the
patient's trajectory following a cancer diagnosis. Systemic cancer treatment and …

STUDY QUESTION Is it possible to identify new mutations potentially associated with non-
syndromic primary ovarian insufficiency (POI) via whole-exome sequencing (WES) …

The Wt1 gene encodes a nuclear transcription factor that is specifically expressed in ovarian
granulosa cells. However, the physiological significance of Wt1 in ovarian follicle …

The vertebrate ovary is an extremely dynamic organ in which excessive or defective follicles
are rapidly and effectively eliminated early in ontogeny and thereafter continuously …