Epigenetic regulation orchestrates gene expression with exquisite precision, over a huge
dynamic range and across developmental space and time, permitting genomically …

In mammals, imprinted genes are regulated by differentially methylated regions (DMRs) that
are inherited from germ cells, leading to monoallelic expression in accordance with parent …

Genomic imprinting is an epigenetic gene-marking phenomenon that occurs in the germline,
whereby genes are expressed from only one of the two parental copies in embryos and …

Recent observations highlight that the mammalian genome extensively communicates with
itself via long-range chromatin interactions. The causal link between such chromatin cross …

Abstract In comparison to Prader–Willi or Angelman syndrome, Russell–Silver syndrome
(RSS) is a relatively “young” imprinting disorder. This congenital disease is characterized by …

Imprinted genes form a special subset of the genome, exhibiting monoallelic expression in a
parent-of-origin–dependent fashion. This monoallelic expression is controlled by parental …

Background DNA methylation has essential roles in transcriptional regulation, imprinting, X
chromosome inactivation and other cellular processes, and aberrant CpG methylation is …

Abstract The Beckwith–Wiedemann syndrome (BWS) is a growth disorder for which an
increased frequency of monozygotic (MZ) twinning has been reported. With few exceptions …

GNAS is a complex imprinted locus leading to several different gene products that show
exclusive monoallelic expression. GNAS also encodes the α-subunit of the stimulatory G …

Imprinting disorders are associated with mutations and epimutations affecting imprinted
genes, that is those whose expression is restricted by parent of origin. Their diagnosis is …