Conjugation of aptamers to homogeneous catalysts (“nucleoapzymes”), heterogeneous
nanoparticle catalysts (“aptananozymes”), and photocatalysts (“photoaptazymes”) yields …

The delivery of cures for retinal diseases remains problematic. There are four main
challenges: passing through multiple barriers of the eye, the delivery to particular retinal cell …

RNA G-quadruplexes (rG4s) are noncanonical secondary structures formed by guanine-rich
sequences that are found in different regions of RNA molecules. These structures have been …

Non-healing wounds have long been the subject of scientific and clinical investigations.
Despite breakthroughs in understanding the biology of delayed wound healing, only limited …

The burden of incidence rate and mortality of cancer is increasing rapidly, and the
development of precise intervention measures for cancer detection and treatment will help …

Cancer remains a highly lethal disease in the world. Currently, either conventional cancer
therapies or modern immunotherapies are non-tumor-targeted therapeutic approaches that …

Aptamers are single-stranded DNA or RNA oligomers that have the ability to generate
unique and diverse tertiary structures that bind to cognate molecules with high specificity. In …

In the current study, polyethylene glycol (PEG) was linked to polylactide (PLA) through the
synthetic peptide PVGLIG which can be selectively cleaved by the tumor-associated matrix …

Aptamer-functionalized Ce4+-ion-modified C-dots act as catalytic hybrid systems,
aptananozymes, catalyzing the H2O2 oxidation of dopamine. A series of aptananozymes …

Herein, a novel targeted delivery system was developed for intracellular co-delivery of
doxorubicin (DOX) as a chemotherapeutic drug, antimiR-21 as an oncogenic antagomiR. In …