Chlorpromazine is a phenothiazine representative drug that can be used to anesthetize and
calm animals. However, chlorpromazine excess may lead to residual persistence in edible …

Background Neuroblastoma (NB) represents the most frequent and aggressive form of
extracranial solid tumor of infants. Nucleolin (NCL) is a protein overexpressed and partially …

The field of targeted protein degradation (TPD) is a rapidly developing therapeutic modality
with the promise to tame disease-relevant proteins in ways that are difficult or impossible to …

A peptide/DNA nanocomplex was developed for the targeted delivery of chemotherapeutics
and photosensitizers to cancer cells for efficient combination therapy. The chemotherapeutic …

The kidney is a vital organ responsible for maintaining homeostasis in the human body.
However, renal cell carcinoma (RCC) is a common malignancy of the urinary system and …

The proteolysis targeting chimeras (PROTACs) technology has been rapidly developed
since its birth in 2001, attracting rapidly growing attention of scientific institutes and …

Aptamers are typically defined as relatively short (20–60 nucleotides) single-stranded DNA
or RNA molecules that bind with high affinity and specificity to various types of targets …

Objectives It is imperative to develop efficient strategies on the treatment of prostate cancer.
Here, we constructed multifunctional nanoparticles, namely AS1411@ MPDA‐DTX (AMD) …

Chimeric antigen receptor T (CAR-T) cell therapy has faced a series of challenges and has
shown very little efficacy in solid tumors to date. Although genetically engineered …

The development of an aptamer-based therapeutic has rapidly progressed following the first
two reports in the 1990s, underscoring the advantages of aptamer drugs associated with …