Enhanced catalytic efficiency and enantioselectivity of epoxide hydrolase from Agrobacterium radiobacter AD1 by iterative saturation mutagenesis for (R) …
SP Zou, YG Zheng, Q Wu, ZC Wang, YP Xue… - Applied microbiology and …, 2018 - Springer
Enantioselective hydrolysis of epoxides by epoxide hydrolase (EH) is one of the most
attractive approaches for the synthesis of chiral epoxides. So far, attempts to develop an …
attractive approaches for the synthesis of chiral epoxides. So far, attempts to develop an …
Enantioselective, continuous (R)-and (S)-2-butanol synthesis: Achieving high space-time yields with recombinant E. coli cells in a micro-aqueous, solvent-free reaction …
V Erdmann, U Mackfeld, D Rother… - Journal of biotechnology, 2014 - Elsevier
The stereoselective production of (R)-or (S)-2-butanol is highly challenging. A potent
synthesis strategy is the biocatalytic asymmetric reduction of 2-butanone applying alcohol …
synthesis strategy is the biocatalytic asymmetric reduction of 2-butanone applying alcohol …
Engineering of a novel carbonyl reductase with coenzyme regeneration in E. coli for efficient biosynthesis of enantiopure chiral alcohols
P Wei, JX Gao, GW Zheng, H Wu, MH Zong… - Journal of …, 2016 - Elsevier
The novel anti-Prelog stereospecific carbonyl reductase from Acetobacter sp. CCTCC
M209061 was successfully expressed in E. coli combined with glucose dehydrogenase …
M209061 was successfully expressed in E. coli combined with glucose dehydrogenase …
Production of a key chiral intermediate of Betahistine with a newly isolated Kluyveromyces sp. in an aqueous two-phase system
Y Ni, J Zhou, Z Sun - Process Biochemistry, 2012 - Elsevier
(S)-(4-Chlorophenyl)-(pyridin-2-yl) methanol [(S)-CPMA] is an important chiral intermediate
of anti-allergic drug Betahistine. Carbonyl reductase-producing microorganisms were …
of anti-allergic drug Betahistine. Carbonyl reductase-producing microorganisms were …
Biotransformation of α-Bromoacetophenones by the Marine Fungus Aspergillus sydowii
LC Rocha, HV Ferreira, EF Pimenta, RGS Berlinck… - Marine …, 2010 - Springer
The biotransformation reactions of α-bromoacetophenone (1), p-bromo-α-
bromoacetophenone (2), and p-nitro-α-bromoacetophenone (3) by whole cells of the marine …
bromoacetophenone (2), and p-nitro-α-bromoacetophenone (3) by whole cells of the marine …
[HTML][HTML] Carbonyl reductase identification and development of whole-cell biotransformation for highly efficient synthesis of (R)-[3,5-bis(trifluoromethyl)phenyl] ethanol
K Chen, K Li, J Deng, B Zhang, J Lin, D Wei - Microbial Cell Factories, 2016 - Springer
Abstract Background (R)-[3, 5-bis (trifluoromethyl) phenyl] ethanol [(R)-3, 5-BTPE] is a
valuable chiral intermediate for Aprepitant (Emend) and Fosaprepitant (Ivemend) …
valuable chiral intermediate for Aprepitant (Emend) and Fosaprepitant (Ivemend) …
[HTML][HTML] Engineering yield and rate of reductive biotransformation in Escherichia coli by partial cyclization of the pentose phosphate pathway and PTS-independent …
Optimization of yields and productivities in reductive whole-cell biotransformations is an
important issue for the industrial application of such processes. In a recent study with …
important issue for the industrial application of such processes. In a recent study with …
Effective Bioremediation of Endocrine-Disrupting Phthalate Esters, Mediated by Bacillus Strains
MA Surhio, FN Talpur, SM Nizamani, MK Talpur… - Water, air, & soil …, 2017 - Springer
Phthalic acid esters (PAEs) is a class of refractory organic compounds, widely used as
additives or plasticizers in plastic industry. PAEs are ubiquitous endocrine-disrupting …
additives or plasticizers in plastic industry. PAEs are ubiquitous endocrine-disrupting …
Efficient biocatalytic synthesis of (R)-[3,5-bis(trifluoromethyl)phenyl] ethanol by a newly isolated Trichoderma asperellum ZJPH0810 using dual cosubstrate: ethanol …
J Li, P Wang, JY He, J Huang, J Tang - Applied microbiology and …, 2013 - Springer
Abstract (R)-[3, 5-bis (trifluoromethyl) phenyl] ethanol is a crucial intermediate for the
synthesis of Aprepitant. An efficient biocatalytic process for (R)-[3, 5-bis (trifluoromethyl) …
synthesis of Aprepitant. An efficient biocatalytic process for (R)-[3, 5-bis (trifluoromethyl) …
Chiral Chlorohydrins from the biocatalyzed reduction of Chloroketones: chiral building blocks for antiretroviral drugs
AS de Miranda, RC Simon, B Grischek… - …, 2015 - Wiley Online Library
E. coli cells that contain overexpressed alcohol dehydrogenases (ADHs) were screened as
biocatalysts for the stereoselective reduction of chloroketones 5 a–d, the corresponding …
biocatalysts for the stereoselective reduction of chloroketones 5 a–d, the corresponding …