[HTML][HTML] Polyphenols: benefits to the cardiovascular system in health and in aging

S Khurana, K Venkataraman, A Hollingsworth, M Piche… - Nutrients, 2013 - mdpi.com
Numerous studies have demonstrated the importance of naturally occurring dietary
polyphenols in promoting cardiovascular health and emphasized the significant role these …

[HTML][HTML] Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases

BNM Zordoky, IM Robertson, JRB Dyck - Biochimica et Biophysica Acta …, 2015 - Elsevier
Cardiovascular disease is the leading cause of death worldwide. Despite advancements in
diagnosis and treatment of cardiovascular disease, the incidence of cardiovascular disease …

Cardiovascular effects and molecular targets of resveratrol

H Li, N Xia, U Förstermann - Nitric oxide, 2012 - Elsevier
Resveratrol (3, 5, 4′-trihydroxy-trans-stilbene) is a polyphenol phytoalexin present in a
variety of plant species and has been implicated to explain the health benefits of red wine. A …

Resveratrol and cardiovascular health–promising therapeutic or hopeless illusion?

PCT Tang, YF Ng, S Ho, M Gyda, SW Chan - Pharmacological research, 2014 - Elsevier
Abstract Resveratrol (3, 5, 4′-trihydroxy-trans-stilbene) is a natural polyphenolic compound
that exists in Polygonum cuspidatum, grapes, peanuts and berries, as well as their …

Resveratrol attenuates myocardial ischemia/reperfusion injury through up-regulation of vascular endothelial growth factor B

L Yang, Y Zhang, M Zhu, Q Zhang, X Wang… - Free Radical Biology …, 2016 - Elsevier
The objective was to examine the protective effect of resveratrol (RSV) on myocardial
ischemia/reperfusion (IR) injury and whether the mechanism was related to vascular …

[HTML][HTML] Resveratrol alleviates sepsis-induced acute lung injury by suppressing inflammation and apoptosis of alveolar macrophage cells

L Yang, Z Zhang, Y Zhuo, L Cui, C Li, D Li… - American journal of …, 2018 - ncbi.nlm.nih.gov
Sepsis is a major cause of death in intensive care units. The purpose of this study was to
investigate the effect of resveratrol (RSV) on sepsis-induced acute lung injury (ALI). The …

Long‐term oral resveratrol intake provides nutritional preconditioning against myocardial ischemia/reperfusion injury: Involvement of VDAC1 downregulation

Z Liao, D Liu, L Tang, D Yin, S Yin, S Lai… - Molecular nutrition & …, 2015 - Wiley Online Library
Scope This study elucidates the effects of long‐term nutritional preconditioning by
resveratrol on ischemia/reperfusion (I/R) injury and its underlying mechanisms. Methods and …

Anti-atherosclerotic plants which modulate the phenotype of vascular smooth muscle cells

TS Al-Shehabi, R Iratni, AH Eid - Phytomedicine, 2016 - Elsevier
Background: Cardiovascular disease (CVD) remains the leading cause of global death, with
atherosclerosis being a major contributor to this mortality. Several mechanisms are …

Pharmacokinetics and tissue distribution of resveratrol, emodin and their metabolites after intake of Polygonum cuspidatum in rats

SP Lin, PM Chu, SY Tsai, MH Wu, YC Hou - Journal of ethnopharmacology, 2012 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: The rhizome of Polygonum cuspidatum SIEB.
et ZUCC.(Polygonaceae, PC), a widely used Chinese medicine, is commonly prescribed for …

[HTML][HTML] Increased aerobic glycolysis is important for the motility of activated VSMC and inhibited by indirubin-3′-monoxime

EH Heiss, D Schachner, M Donati, CS Grojer… - Vascular …, 2016 - Elsevier
Increased aerobic glycolysis is a recognized feature of multiple cellular phenotypes and
offers a potential point for drug interference, as pursued by anti-tumor agents targeting the …